Document Detail

Update on negative-pressure wound therapy.
MedLine Citation:
PMID:  21200280     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Over the last 15 years, negative-pressure wound therapy has become commonly used for treatment of a wide variety of complex wounds. There are now several systems marketed, and additional products will be available in the near future. Many clinicians have noted a dramatic response when negative-pressure wound therapy technology has been used, prompting a number of scientific investigations related to its mechanism of action and clinical trials determining its efficacy.
METHODS: The peer-reviewed literature within the past 5 years was reviewed, using an evidence-based approach.
RESULTS: Negative-pressure wound therapy works through mechanisms that include fluid removal, drawing the wound together, microdeformation, and moist wound healing. Several randomized clinical trials support the use of negative-pressure wound therapy in certain wound types. Serious complications, including bleeding and infection, have recently been reported by the U.S. Food and Drug Administration in a small number of patients.
CONCLUSIONS: Negative-pressure wound therapy has dramatically changed the way complex wounds are treated. The rapid introduction of this technology has occurred faster than large-scale randomized controlled studies or registry studies have been conducted. Further clinical studies and basic science studies will help surgeons to better understand the evidence and use this technology in the future.
Dennis P Orgill; Lauren R Bayer
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Plastic and reconstructive surgery     Volume:  127 Suppl 1     ISSN:  1529-4242     ISO Abbreviation:  Plast. Reconstr. Surg.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-04     Completed Date:  2011-02-24     Revised Date:  2014-10-13    
Medline Journal Info:
Nlm Unique ID:  1306050     Medline TA:  Plast Reconstr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  105S-115S     Citation Subset:  AIM; IM    
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MeSH Terms
Negative-Pressure Wound Therapy* / trends
Wound Healing
Wounds and Injuries / physiopathology,  therapy*
Comment In:
Plast Reconstr Surg. 2011 Jan;127 Suppl 1:116S   [PMID:  21200281 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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