| Update lecture: benign diseases of the exocrine pancreas. | |
| | |
MedLine Citation:
|
PMID: 22104746 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
A brief overview on the physiology and regulation of digestive enzyme secretion by the exocrine pancreas is presented. Knowledge about the physiology of the exocrine pancreas should help for a better understanding of the pathophysiology of both acute and chronic pancreatitis. In the pathophysiology of acute pancreatitis, fusion of zymogen granules with lysosomes, which leads to intracellular activation of trypsinogen, is still regarded as a key step in pathophysiology. The role of activation by cathepsins and the role of autoactivation of trypsinogen are still under debate. Studies on genetic alterations in various forms of human chronic pancreatitis can be interpreted that an imbalance between protease inhibitors and active proteases plays a key role. Toxic Ca(2+) signals by excessive liberation from the endoplasmic reticulum may play another role. The mortality of necrotizing pancreatitis is still high. Early mortality is caused by a systemic inflammatory response syndrome with or without concomitant infection of necrosis; late mortality by multi-organ failure syndrome due to sepsis. Therapy of necroses should be performed as late as possible. A step-up approach using CT-guided and/or transgastric endoscopic necrosectomy seems to be superior to a primary surgical approach. A brief overview of the German S3 guidelines, not yet published, regarding diagnosis and treatment of chronic pancreatitis is presented. |
| | |
Authors:
|
Joachim Mössner |
Related Documents
:
|
20614396 - Snakebite doesn't cause disseminated intravascular coagulation: coagulopathy and thromb... 1666726 - Occurrence of hereditary leaky red cell syndrome and partial coagulation factor vii def... 11198526 - Localization of clinical syndromes using dwi: two examples of the "capsular" warning sy... 21740396 - Unexplained acute respiratory distress syndrome after varicocele surgery; report of a c... 7798116 - Electrophysiological evidence of "nerve entrapment syndromes" and subclinical periphera... 21556356 - Pan-european distribution of white-nose syndrome fungus (geomyces destructans) not asso... |
Publication Detail:
|
Type: Journal Article Date: 2011-11-15 |
Journal Detail:
|
Title: Digestive diseases (Basel, Switzerland) Volume: 29 Suppl 1 ISSN: 1421-9875 ISO Abbreviation: Dig Dis Publication Date: 2011 |
Date Detail:
|
Created Date: 2011-11-22 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8701186 Medline TA: Dig Dis Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 9-16 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 S. Karger AG, Basel. |
Affiliation:
|
Division of Gastroenterology and Rheumatology, Department of Medicine, Neurology and Dermatology, University Hospital Leipzig, Leipzig, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Update in biliary endoscopy.
Next Document: Capsule endoscopy and Crohn's disease.