Document Detail


Update on infantile colic and management options.
MedLine Citation:
PMID:  17979025     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Infant colic is a common but poorly defined and understood clinical entity and, while several causative factors have been suggested, a unifying theory of its pathogenesis is still required. Food hypersensitivity/allergy and gut dysmotility are the lead contenders for causative factors of infantile colic. Additional confounders and covariables include psychological and social factors. Although the available data fail to provide insight into the exact triggers of infantile colic, these do allow for the hypothesis that certain infants are predisposed to dietary protein intolerance and disturbed gut motility, such as visceral hypersensitivity/ hyperalgesia, in the first few weeks of life. These processes lead to distress and altered perceptions, where normal stimuli (ie, intestinal distension) are misinterpreted as painful events. This review discusses a number of interventions, including pharmacological agents, which are based on the perceived pathogenesis; however, it is likely that infants with colic will require a multifactorial management strategy. Healthcare providers must offer support, reassurance and empathy to the caregiver, and adopt a biopsychosocial approach to the infants and their families by considering any underlying medical diseases in addition to examining the family unit. In a small subset of infants with colicky behavior, a specific medical disorder such as gastroesophageal reflux or milk protein allergy may be identified. While the vast majority of infants with colic will recover uneventfully, some may be at risk for the later development of behavioral problems and atopy/allergy.
Authors:
Sandeep K Gupta
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in investigational drugs (London, England : 2000)     Volume:  8     ISSN:  1472-4472     ISO Abbreviation:  Curr Opin Investig Drugs     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-05     Completed Date:  2008-01-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100965718     Medline TA:  Curr Opin Investig Drugs     Country:  England    
Other Details:
Languages:  eng     Pagination:  921-6     Citation Subset:  IM    
Affiliation:
James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Division of Pediatric Gastroenterology/Hepatology/Nutrition, Room ROC 4210, 702 Barnhill Drive, Indianapolis, IN 46202-5225, USA. sgupta@iupui.edu
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MeSH Terms
Descriptor/Qualifier:
Colic / complications,  pathology*,  therapy*
Gastroesophageal Reflux / complications,  diagnosis
Humans
Infant
Milk Hypersensitivity / complications,  diagnosis
Primary Prevention / methods
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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