| Update in the treatment of venous thromboembolism. | |
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MedLine Citation:
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PMID: 18302085 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This review describes recent evidence relevant to the treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE). Because venous thromboembolism (VTE) is a spectrum of disease that includes both of these disorders, many of the therapeutic options are common to both. At the time of diagnosis, effective treatment options for patients with VTE include unfractionated heparin, low molecular weight heparins (e.g., dalteparin, enoxaparin, tinzaparin), and pentasaccharides (e.g., fondaparinux). Many patients with VTE, especially DVT, can receive most or all of their initial treatment as outpatients. Other treatment strategies such as vena caval filter placement and mechanical (or chemical) clot dissolution are discussed briefly. Anticoagulation with warfarin (or other oral vitamin K antagonists) is a highly effective strategy for the long-term prevention of VTE recurrence in most patients. In addition to presenting evidence relevant to the optimal duration of warfarin therapy, we highlight circumstances under which extended therapy with a parenteral agent such as a low molecular weight heparin might be preferable. |
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Authors:
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David A Garcia; Alex C Spyropoulos |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Seminars in respiratory and critical care medicine Volume: 29 ISSN: 1069-3424 ISO Abbreviation: Semin Respir Crit Care Med Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-02-27 Completed Date: 2008-06-17 Revised Date: 2009-06-13 |
Medline Journal Info:
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Nlm Unique ID: 9431858 Medline TA: Semin Respir Crit Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 40-6 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA. davgarcia@salud.unm.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anticoagulants
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therapeutic use* Heparin, Low-Molecular-Weight / therapeutic use Humans Pulmonary Embolism / drug therapy* Venous Thromboembolism / drug therapy* Venous Thrombosis / drug therapy* Warfarin / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Heparin, Low-Molecular-Weight; 81-81-2/Warfarin |
| Comments/Corrections | |
Erratum In:
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Semin Respir Crit Care Med. 2008 Jun;29(3):319 Note: Dosage error in article text |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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