| Update on idiopathic colitides. | |
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MedLine Citation:
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PMID: 23207597 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: This article summarizes the latest developments for three types of idiopathic colitis: ulcerative colitis, Crohn's disease, and microscopic colitis. RECENT FINDINGS: Crohn's disease and ulcerative colitis are highly related genetically. Colonoscopy remains the gold standard for making a diagnosis. The addition of chromoendoscopy can aid in identification and removal of colonic dysplasia in both disorders. The therapy for ulcerative colitis and Crohn's disease has been transformed with the introduction of anti-TNF treatment. For ulcerative colitis, recent data show that prolonged use of infliximab is effective, well tolerated and that early mucosal healing is associated with decreased risk of colectomy. There is no evidence of a significant increased risk for anti-TNF-induced malignancies. Combination therapy with azathioprine and infliximab for ulcerative colitis has now been shown to be superior to monotherapy. Natalizumab is effective in anti-TNF failures and patients can be risk stratified for progressive multifocal leukoencephalopathy by testing for John Cunningham virus antibodies. Microscopic colitis can often be related to medications, and symptoms may be worsened by coexisting celiac disease. SUMMARY: Combination therapy with an anti-TNF and a thiopurine is currently the most effective treatment for moderate-to-severe Crohn's disease or ulcerative colitis. Stem cell therapy for perianal fistulas in patients with Crohn's disease is a promising new therapy approach. |
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Authors:
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Sebastian Strobel; Maria T Abreu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current opinion in gastroenterology Volume: 29 ISSN: 1531-7056 ISO Abbreviation: Curr. Opin. Gastroenterol. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2012-12-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8506887 Medline TA: Curr Opin Gastroenterol Country: United States |
Other Details:
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Languages: eng Pagination: 60-5 Citation Subset: IM |
Affiliation:
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Division of Gastroenterology, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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