| Update on drugs for overactive bladder syndrome. | |
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MedLine Citation:
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PMID: 17583229 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Around 1.5% of adults in Europe and the USA have urge urinary incontinence (involuntary leakage immediately preceded or accompanied by urgency). This is usually due to overactive bladder syndrome (defined as urgency, with or without urge incontinence, and usually with frequency and nocturia), which occurs in around 12% of adults, and is similarly prevalent in men and women. We last reviewed this condition in 2001. Since then, two new antimuscarinic drugs, darifenacin (Emselex) and solifenacin (Vesicare) have been licensed in the UK for urge incontinence and/or increased urinary frequency and urgency (as may occur in patients with overactive bladder syndrome), as have transdermal oxybutynin (Kentera) and modified-release formulations of tolterodine (Detrusitol XL) and propiverine (Detrunorm XL). Here we review the place of these newer drugs and formulations. |
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Authors:
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Drug and therapeutics bulletin Volume: 45 ISSN: 0012-6543 ISO Abbreviation: Drug Ther Bull Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-06-22 Completed Date: 2007-11-21 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0112037 Medline TA: Drug Ther Bull Country: England |
Other Details:
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Languages: eng Pagination: 44-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Benzhydryl Compounds
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therapeutic use Benzilates / therapeutic use Benzofurans / therapeutic use Cholinergic Antagonists / therapeutic use* Cresols / therapeutic use Humans Mandelic Acids / therapeutic use Muscarinic Antagonists / therapeutic use* Phenylpropanolamine / therapeutic use Pyrrolidines / therapeutic use Quinuclidines / therapeutic use Randomized Controlled Trials as Topic Tetrahydroisoquinolines / therapeutic use Urinary Bladder, Overactive / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Benzhydryl Compounds; 0/Benzilates; 0/Benzofurans; 0/Cholinergic Antagonists; 0/Cresols; 0/Mandelic Acids; 0/Muscarinic Antagonists; 0/Pyrrolidines; 0/Quinuclidines; 0/Tetrahydroisoquinolines; 0/quinuclidin-3'-yl-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate monosuccinate; 124937-51-5/tolterodine; 133099-04-4/darifenacin; 14838-15-4/Phenylpropanolamine; 5633-20-5/oxybutynin; 60569-19-9/propiverine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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