Document Detail

Update of daily intake of PCDDs, PCDFs, and dioxin-like PCBs from food in Japan.
MedLine Citation:
PMID:  11695626     Owner:  NLM     Status:  MEDLINE    
Total diet study (TDS) samples of 14 food groups from 16 locations in Japan, collected in 1999 and 2000, were analyzed for polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and dioxin-like polychlorinated biphenyls (dioxin-like PCBs) to estimate the update of daily intake of these contaminants from food. The mean daily intake of toxic equivalency (TEQ) for an adult weighing 50 kg, calculated at non-detected isomer concentrations equal to zero (ND = 0), was estimated to be 2.25 pg TEQ/kg b.w./day. When non-detected isomer concentrations are assumed to be equal to half of the limits of detection (ND = 1/2 LOD), the mean daily intake was estimated to be 3.22 pg TEQ/kg b.w./day. These values were below the tolerable daily intake (TDI) of 4 pg TEQ/kg b.w. for PCDD/Fs and dioxin-like PCBs set in Japan. In both the estimates, the mean daily intakes were highest from fish and shellfish (76.9% at ND = 0 and 53.9% at ND = 1/2 LOD of the total TEQs), followed by those from meat and eggs (15.5% at ND = 0 and 11.7% at ND = 1/2 LOD of the total TEQs). Congener specific data revealed that these total TEQ levels were dominated by 1,2,3,7,8-PeCDD, 2,3,4,7,8-PeCDF and 3,3',4,4',5-PeCB in each case (71.7% at ND = 0 and 63.1% at ND = 1/2 LOD of the total TEQs). The dioxin-like PCBs (non-ortho and mono-ortho PCBs) accounted for about 50% of these total TEQs. These data will be very useful in the risk assessment of PCDD/Fs and dioxin-like PCBs from food in Japan.
T Tsutsumi; T Yanagi; M Nakamura; Y Kono; H Uchibe; T Iida; T Hori; R Nakagawa; K Tobiishi; R Matsuda; K Sasaki; M Toyoda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chemosphere     Volume:  45     ISSN:  0045-6535     ISO Abbreviation:  Chemosphere     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-11-06     Completed Date:  2002-02-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0320657     Medline TA:  Chemosphere     Country:  England    
Other Details:
Languages:  eng     Pagination:  1129-37     Citation Subset:  IM    
Division of Foods, National Institute of Health Sciences, Tokyo, Japan.
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MeSH Terms
Benzofurans / analysis*,  pharmacokinetics
Environmental Exposure*
Environmental Pollutants / analysis*,  pharmacokinetics
Food Contamination*
Polychlorinated Biphenyls / analysis*,  pharmacokinetics
Risk Assessment
Tetrachlorodibenzodioxin / analogs & derivatives*,  analysis*,  pharmacokinetics
Reg. No./Substance:
0/Benzofurans; 0/Environmental Pollutants; 0/Polychlorinated Biphenyls; 0/chlorinated dibenzofurans; 0/polychlorodibenzo-4-dioxin; 1746-01-6/Tetrachlorodibenzodioxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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