Document Detail


Update: biomarkers for idiopathic inflammatory myopathies.
MedLine Citation:
PMID:  23018857     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: Establishing diagnoses and distinguishing active disease from chronic injury remain significant clinical challenges in idiopathic inflammatory myopathies (IIM). Recent 'discovery' approaches utilizing novel genomic and proteomic techniques have revealed candidate molecular biomarkers to augment clinical and classical histological data.
RECENT FINDINGS: Whole blood and serum Type 1 interferons (IFN-1) and IFN-1 inducible genes are gaining traction as disease biomarkers in IIM. IFNβ is emerging as a disease activity marker specifically for dermatomyositis. Recently, molecules associated with innate immune-cell function, including TLR-3, high mobility group box (HMGB)-1, B7 Homolog 1, S100A4, and resistin have been detected in tissues of dermatomyositis patients. Serum Interleukin-17 (IL-17) and IL-23 correlate with active disease in early IIM. Antibodies recognizing the Survival Motor Neuron complex have been newly identified in a subset of patients with polymyositis. Protein aggregates are potential disease activity sensors for inclusion body myositis. Skin and lung harbor potential biomarkers for IIM.
SUMMARY: Recent advances in understanding the pathogenesis of IIM have led to discovery of molecules that are candidate biomarkers of disease activity. Type 1 interferon and myeloid-cell signatures are leading candidate markers for use in IIM activity monitoring.
Authors:
Rawad Nasr; Ann M Reed; Erik J Peterson
Related Documents :
24082197 - A case of adult-onset still's disease presenting with urticated plaques and acute myope...
23278117 - An overview of the modulatory effects of oleic acid in health and disease.
23018857 - Update: biomarkers for idiopathic inflammatory myopathies.
24164387 - Advances in understanding the pathogenesis of autoimmune disorders: focus on chemokines...
6787337 - Abnormal copper metabolism in cultured fibroblasts from patients with wilson's disease.
12705757 - Dyskeratosis congenita associated with three malignancies.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current opinion in rheumatology     Volume:  24     ISSN:  1531-6963     ISO Abbreviation:  Curr Opin Rheumatol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-09-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9000851     Medline TA:  Curr Opin Rheumatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  609-15     Citation Subset:  IM    
Affiliation:
aDivision of Rheumatology, Department of Medicine, University of Minnesota, Minneapolis bDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester cDepartment of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota, Minneapolis, Minnesota, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Development of Novel Carbon Fiber produced from Waste Fiber by Cabonization.
Next Document:  Morphea and other localized forms of scleroderma.