Document Detail


Update on animal models for testing innovative antineoplastic strategies: the mammary tumor in dogs
MedLine Citation:
PMID:  11824064     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study, the authors describe a new possible animal model to test new anticancer therapies. The selected animals are domestic animals such as dogs, which develop spontaneous tumours very similar in morphology and biology to human ones, also in relation to similar environmental oncogenic pressures. Cycline D1 overexpression, which has both a prognostic and pathogenetic value, is usually detected in human tumours. Thus, the use of cycline-dependent kinases inhibitors could be of value in anticancer therapy. We studied spontaneous canine mammary tumours in order to test the above hypothesis. Immunohistochemistry, AgNOR and western blotting analysis were performed, and the results revealed that cycline D1 is associated with metabolic, morphological and protein expression patterns typical of proliferating cells. The same protein expression pattern, the use of human antibodies for detecting canine proteins and the availability of neoplastic tissue make these spontaneous canine tumours a reliable model.
Authors:
A Sfacteria; B Cervasi; C Bertani; M Paiardini; G Costantino; A Piedimonte; G De Vico
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Chirurgia italiana     Volume:  53     ISSN:  0009-4773     ISO Abbreviation:  Chir Ital     Publication Date:    2001 Nov-Dec
Date Detail:
Created Date:  2002-02-04     Completed Date:  2002-07-31     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0151753     Medline TA:  Chir Ital     Country:  Italy    
Other Details:
Languages:  ita     Pagination:  857-68     Citation Subset:  IM    
Affiliation:
Dipartimento di Patologia, Mal. Infet. e Paras., Ispezione degli Alimenti di O.A. Sezione di Patologia, Università di Messina, Facoltà di Medicina Veterinaria, Via Santa Cecilia, 30, 98123 Messina.
Vernacular Title:
Messa a punto di modelli animali per la sperimentazione di strategie antineoplastiche innovative: il tumore mammario canino.
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MeSH Terms
Descriptor/Qualifier:
Animals
Disease Models, Animal*
Dogs
Female
Mammary Neoplasms, Experimental / genetics,  pathology,  therapy*

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