| Update on the role of endothelial lipase in high-density lipoprotein metabolism, reverse cholesterol transport, and atherosclerosis. | |
| | |
MedLine Citation:
|
PMID: 20962428 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Endothelial lipase (EL) is a phospholipase that belongs to the lipoprotein lipase (LPL) family, which includes LPL and hepatic lipase (HL). Similar to LPL and HL, EL regulates lipoprotein metabolism, mainly high-density lipoprotein (HDL) metabolism and HDL cholesterol (HDL-C) levels in humans and mice. Existing data strongly suggest that inhibition of EL in humans would be expected to increase the HDL-C level. However, it has not been definitively established whether the effect of EL activity on HDL-C levels translates into effects on reverse cholesterol transport or atherosclerosis. The available data regarding the impact of EL expression and activity on HDL metabolism, reverse cholesterol transport, and atherosclerosis are reviewed. |
| | |
Authors:
|
Tomoyuki Yasuda; Tatsuro Ishida; Daniel J Rader |
Related Documents
:
|
20385548 - Exchange of apolipoprotein a-i between lipid-associated and lipid-free states: a potent... 17329618 - Inability of hdl from abdominally obese subjects to counteract the inhibitory effect of... 1596518 - Changes in particle size of high density lipoproteins during incubation with very low d... 7175378 - Separation and quantitation of subclasses of human plasma high density lipoproteins by ... 20833768 - Influence of processing method on comparative digestion of white corn versus convention... 11999538 - Contribution of meals and snacks to nutrient intake of male and female elite figure ska... |
Publication Detail:
|
Type: Journal Article; Review Date: 2010-10-15 |
Journal Detail:
|
Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 74 ISSN: 1347-4820 ISO Abbreviation: Circ. J. Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-10-29 Completed Date: 2010-11-30 Revised Date: 2011-02-18 |
Medline Journal Info:
|
Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
|
Languages: eng Pagination: 2263-70 Citation Subset: IM |
Affiliation:
|
Institute for Translational Medicine and Therapeutics and Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Atherosclerosis / drug therapy, enzymology*, genetics Biological Transport Cardiovascular Agents / pharmacology Cholesterol / metabolism* Endothelium, Vascular / drug effects, enzymology* Enzyme Inhibitors / pharmacology Humans Lipase / antagonists & inhibitors, genetics, metabolism* Lipoproteins, HDL / metabolism* Mice Polymorphism, Single Nucleotide |
| Chemical | |
Reg. No./Substance:
|
0/Cardiovascular Agents; 0/Enzyme Inhibitors; 0/Lipoproteins, HDL; 57-88-5/Cholesterol; EC 3.1.1.-/LIPG protein, human; EC 3.1.1.-/Lipg protein, mouse; EC 3.1.1.3/Lipase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Developmental origins of cardiovascular disease: cholesterol metabolism and higher carotid artery in...
Next Document: Aging and arterial stiffness.