| Update on Rifampin, Rifabutin, and Rifapentine Drug Interactions. | |
| | |
MedLine Citation:
|
PMID: 23136913 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Abstract Background: Rifampin is a potent inducer of both cytochrome P-450 oxidative enzymes and the P-glycoprotein transport system. Among numerous well-documented, clinically significant interactions, examples include warfarin, oral contraceptives, itraconazole, digoxin, verapamil, simvastatin, and human immunodeficiency virus-related protease inhibitors. Rifabutin reduces serum concentrations of antiretroviral agents, but less so than rifampin. Rifapentine is also an inducer of drug metabolism. Methods: A literature search of English language journals from 2008 to March 2012 was completed using several databases, including PubMed, EMBASE, and SCOPUS. Search terms included rifampin, rifabutin, rifapentine AND drug interactions. Findings: Examples of clinically relevant interactions with rifampin demonstrated by recent reports include posaconazole, voriconazole, oxycodone, risperidone, mirodenafil, and ebastine. Conclusions: To avoid a reduced therapeutic response, therapeutic failure, or toxic reactions when rifampin, rifabutin, or rifapentine are added to or discontinued from medication regimens, clinicians need to be aware of these interactions. Recent studies have indicated that other transporter systems play a role in these drug interactions. As reports of rifampin drug interactions continue to grow, this review is a reminder to clinicians to be vigilant. |
| | |
Authors:
|
Anne M Baciewicz; Cary R Chrisman; Christopher K Finch; Timothy H Self |
Related Documents
:
|
4058743 - Patterns of seizure activation after withdrawal of antiepileptic medication. 8518603 - Prognostic index for recurrence of seizures after remission of epilepsy. medical resear... 9315233 - Cellular accumulation and biological activity of hematoporphyrin derivative(l) in compa... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-11-9 |
Journal Detail:
|
Title: Current medical research and opinion Volume: - ISSN: 1473-4877 ISO Abbreviation: Curr Med Res Opin Publication Date: 2012 Nov |
Date Detail:
|
Created Date: 2012-11-9 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0351014 Medline TA: Curr Med Res Opin Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Meta-analysis: Efficacy of small bowel preparation for small bowel video capsule endoscopy.
Next Document: Family-based models for childhood-obesity intervention: a systematic review of randomized controlled...