| Update on Renin-Angiotensin-aldosterone blockade in heart failure. | |
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MedLine Citation:
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PMID: 19930983 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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There is convincing evidence that the renin-angiotensin-aldosterone system (RAAS) plays an important role in heart failure (HF), from the events that result in its inception through advanced disease. In particular, RAAS activation is one of the major pathways involved in maladaptive cardiac remodeling, a process that results in progressive cardiac dysfunction. Not surprisingly, strategies targeting the RAAS have substantial benefits in HF. These therapies, which include angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and aldosterone receptor antagonists, have emerged as cornerstones of HF therapy, particularly in patients with systolic dysfunction. Their role in HF with preserved ejection fraction, however, is less certain. New information and approaches targeting RAAS activation continue to emerge. Direct renin inhibitors are hypothesized to have beneficial effects in HF, but further studies are needed to evaluate their efficacy. |
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Authors:
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Young-Sin Kim; Barry Greenberg |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current treatment options in cardiovascular medicine Volume: 11 ISSN: 1534-3189 ISO Abbreviation: Curr Treat Options Cardiovasc Med Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9815942 Medline TA: Curr Treat Options Cardiovasc Med Country: United States |
Other Details:
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Languages: eng Pagination: 455-66 Citation Subset: - |
Affiliation:
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Barry Greenberg, MD Advanced Heart Failure Treatment Program, University of California, San Diego, 200 West Arbor Street, San Diego, CA 92103, USA. bgreenberg@ucsd.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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