Document Detail


Update on the performance and application of basophil activation tests.
MedLine Citation:
PMID:  23188565     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The basophil activation test (BAT) is a flow-cytometry-based functional assay that assesses the degree of cell activation after exposure to a stimuli. Though no standardized technique currently exists, recent advances have improved the performance of this assay, including identification of new basophil-specific markers and comparisons of the expression of CD63 to CD203c during activation. The basophil activation test has also been validated for many IgE-mediated disease conditions, which have been extensively reviewed elsewhere. This review focuses on the most recent applications of this test to the diagnosis of allergy to drugs, foods, venoms, and pollens, and the evolving role of the BAT in monitoring immunotherapy.
Authors:
Emily C McGowan; Sarbjit Saini
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current allergy and asthma reports     Volume:  13     ISSN:  1534-6315     ISO Abbreviation:  Curr Allergy Asthma Rep     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-14     Completed Date:  2013-04-17     Revised Date:  2014-07-03    
Medline Journal Info:
Nlm Unique ID:  101096440     Medline TA:  Curr Allergy Asthma Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  101-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Allergens / immunology
Antigens, CD63 / metabolism
Basophils / immunology*
Biological Markers / metabolism
Flow Cytometry / methods
Humans
Hypersensitivity, Immediate / diagnosis*,  immunology
Immunologic Tests*
Phosphoric Diester Hydrolases / metabolism
Pyrophosphatases / metabolism
Grant Support
ID/Acronym/Agency:
R21 AI088604/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Allergens; 0/Antigens, CD63; 0/Biological Markers; 0/CD63 protein, human; 0/ENPP3 protein, human; EC 3.1.4.-/Phosphoric Diester Hydrolases; EC 3.6.1.-/Pyrophosphatases
Comments/Corrections

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