Document Detail

An update on the evaluation and management of pulmonary hypertension in scleroderma.
MedLine Citation:
PMID:  22215445     Owner:  NLM     Status:  MEDLINE    
Pulmonary arterial hypertension associated with scleroderma (SScPAH) is a debilitating, highly lethal condition that responds to an array of therapies. Quality of life and prognosis are substantially improved by treatment, and early diagnosis and treatment are associated with improved outcomes. There are serious limitations to current screening programs. Many more questions need to be addressed. Why is PAH so common in SSc? Why is the tolerance of pulmonary hypertension so poor in scleroderma? What are the best measures of response to therapy in SSc patients with PAH? Should we use different parameters in prognostic scores in SScPAH? Why is postcapillary pulmonary hypertension so common in SSc? How do we reliably differentiate lung disease-associated pulmonary hypertension from PAH? The aim of this review is to summarize the main areas of progress over the past decade and to look to the challenges for the next decade.
John G Coghlan; Benjamin Schreiber; Benjamin Schrieber
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current rheumatology reports     Volume:  14     ISSN:  1534-6307     ISO Abbreviation:  Curr Rheumatol Rep     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-10     Completed Date:  2012-05-08     Revised Date:  2012-06-11    
Medline Journal Info:
Nlm Unique ID:  100888970     Medline TA:  Curr Rheumatol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-10     Citation Subset:  IM    
Department of Cardiology, Royal Free Hospital, London NW3 2QG, England, UK.
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MeSH Terms
Hypertension, Pulmonary* / diagnosis,  drug therapy,  etiology
Scleroderma, Systemic / complications*
Erratum In:
Curr Rheumatol Rep. 2012 Jun;14(3):294
Note: Schrieber, Benjamin [corrected to Schreiber, Benjamin]

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