Document Detail

Update -- AIDS treatment and epidemiology.
MedLine Citation:
PMID:  12287809     Owner:  PIP     Status:  MEDLINE    
This update on AIDS treatment and epidemiology reviews the status of zidovudine (AZT) treatment effectiveness, tuberculosis and HIV, vaccine development, vertical HIV transmission, and sexually transmitted diseases (STD) and HIV transmission. The European multicenter Concorde trial of AZT involving 1749 people followed over a three-year period found no difference in time progression of AIDS or survival in the AZT-treated versus placebo group. On tuberculosis (TB), HIV-induced immunosuppression is the highest risk factor for activation of latent infection and disease. The disease then progresses faster in HIV-seropositive individuals and is more severe and difficult to treat than in people not infected with HIV. Non-compliance with treatment is resulting in a rise in multiple drug resistant TB. With six major subtypes of HIV-1 identified, it will be several years before a safe and effective vaccine against HIV may be available. The risk of HIV-1 transmission from mother to child is reported to range from 15-20% in Europe, 25-39% in Africa, and 16-30% in the US; the risk of HIV-2 transmission, however, is less than 5%. It appears that increased risk of transmission is associated with advanced maternal disease status, p-24 antigenaemia, premature delivery, and breastfeeding, yet no single factor is predictive. Evidence indicates that women who become infected with HIV during the time they are breastfeeding are twice as likely to transmit the virus to theirs infant than women who were infected before beginning breastfeeding. Finally, STDs increase the risk of HIV transmission, but the causative mechanisms are poorly understood. STD prevention and control measures should be taken accordingly.
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  African journal of medical practice / African Academy of Sciences     Volume:  1     ISSN:  1023-8190     ISO Abbreviation:  Afr J Med Pract     Publication Date:    1994 Mar-Apr
Date Detail:
Created Date:  1994-12-01     Completed Date:  1994-12-01     Revised Date:  2013-03-06    
Medline Journal Info:
Nlm Unique ID:  9439289     Medline TA:  Afr J Med Pract     Country:  KENYA    
Other Details:
Languages:  eng     Pagination:  33     Citation Subset:  J    
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MeSH Terms
Acquired Immunodeficiency Syndrome*
Breast Feeding*
HIV Infections*
Infant Nutritional Physiological Phenomena
Infectious Disease Transmission, Vertical*
Nutritional Physiological Phenomena
Pharmaceutical Preparations*
Sexually Transmitted Diseases*
Virus Diseases
Reg. No./Substance:
0/Pharmaceutical Preparations; 0/Vaccines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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