| Upconversion nanoparticles: synthesis, surface modification and biological applications. | |
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MedLine Citation:
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PMID: 21419877 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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New generation fluorophores, also termed upconversion nanoparticles (UCNPs), have the ability to convert near infrared radiations with lower energy into visible radiations with higher energy via a nonlinear optical process. Recently, these UCNPs have evolved as alternative fluorescent labels to traditional fluorophores, showing great potential for imaging and biodetection assays in both in vitro and in vivo applications. UCNPs exhibit unique luminescent properties, including high penetration depth into tissues, low background signals, large Stokes shifts, sharp emission bands, and high resistance to photobleaching, making UCNPs an attractive alternative source for overcoming current limitations in traditional fluorescent probes. In this article, we discuss the recent progress in the synthesis and surface modification of rare-earth doped UCNPs with a specific focus on their biological applications. FROM THE CLINICAL EDITOR: Upconversion nanoparticles - a new generation of fluorophores - convert near infrared radiations into visible radiations via a nonlinear optical process. These UCNPs have evolved as alternative fluorescent labels with great potential for imaging and biodetection assays in both in vitro and in vivo applications. |
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Authors:
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Meng Wang; Gopal Abbineni; April Clevenger; Chuanbin Mao; Shukun Xu |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review Date: 2011-03-17 |
Journal Detail:
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Title: Nanomedicine : nanotechnology, biology, and medicine Volume: 7 ISSN: 1549-9642 ISO Abbreviation: Nanomedicine Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-11-28 Completed Date: 2012-03-13 Revised Date: 2013-02-19 |
Medline Journal Info:
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Nlm Unique ID: 101233142 Medline TA: Nanomedicine Country: United States |
Other Details:
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Languages: eng Pagination: 710-29 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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College of Sciences, Northeastern University, Shenyang, People's Republic of China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Diagnostic Imaging / methods Fluorescent Dyes / chemistry*, diagnostic use* Humans Metals, Rare Earth / chemistry*, diagnostic use* Microscopy, Fluorescence / methods Nanoparticles / chemistry*, diagnostic use*, ultrastructure Nanotechnology / methods Surface Properties |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL092526-01A2/HL/NHLBI NIH HHS; R01 HL092526-02/HL/NHLBI NIH HHS; R01HL092526-01A2/HL/NHLBI NIH HHS; R03 AR056848-01/AR/NIAMS NIH HHS; R03 AR056848-02/AR/NIAMS NIH HHS; R03 AR056848-03/AR/NIAMS NIH HHS; R03AR056848-01/AR/NIAMS NIH HHS; R21 EB009909-01A1/EB/NIBIB NIH HHS; R21 EB009909-02/EB/NIBIB NIH HHS; R21EB009909-01A1/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fluorescent Dyes; 0/Metals, Rare Earth |
| Comments/Corrections | |
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