| Up-regulation of prohibitin 1 is involved in the proliferation and migration of liver cancer cells. | |
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MedLine Citation:
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PMID: 21318481 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Although prohibitin 1 (PHB) is known to be associated with tumors, there are few studies regarding the role of PHB in hepatocellular carcinoma. An earlier glycoproteomics study of ours showed that PHB is over-expressed in MHCC97-H cells, a highly metastatic liver cancer cell line, and can be captured by wheat germ agglutinin. In the present study, western blotting and reverse transcription-PCR experiments showed an approximately 2-fold up-regulation in the expression of PHB in MHCC97-H cells. However, PHB was not significantly up-regulated in MHCC97-L cells, a low-metastatic liver cancer cell line. When PHB was over-expressed in MHCC97-L cells, cell proliferation was inhibited by 35% and migration increased about 2-fold. The results of this study show that PHB is up-regulated in MHCC97-H cells and is associated with both proliferation and migration of liver cancer cells. |
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Authors:
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Zhibin Xu; Jinhong Wu; Xiliang Zha |
Publication Detail:
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Type: Journal Article Date: 2011-02-14 |
Journal Detail:
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Title: Science China. Life sciences Volume: 54 ISSN: 1869-1889 ISO Abbreviation: Sci China Life Sci Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101529880 Medline TA: Sci China Life Sci Country: China |
Other Details:
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Languages: eng Pagination: 121-7 Citation Subset: IM |
Affiliation:
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Institute of Biomedical Sciences, Fudan University, Shanghai, 200032, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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