| Upregulation of REG Ialpha accelerates tumor progression in pancreatic cancer with diabetes. | |
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MedLine Citation:
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PMID: 20099282 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Diabetes is now generally accepted as a crucial event in the process of pancreatic cancer (PaC). However, molecular mechanisms underlying the relationship between diabetes and PaC are not fully understood. Regenerating gene (REG) Ialpha is a growth factor affecting pancreatic islet beta cells, and it has been shown to be involved in the carcinogenesis in gastrointestinal tract. It is rational to speculate that REG Ialpha plays a potential role in the pathogenesis of PaC with diabetes. The aim of this study was to evaluate the REG Ialpha protein expression profile in PaC with and without diabetes, and define the contribution of REG Ialpha on PaC development. We found that REG Ialpha protein preferentially expressed in cancerous tissues of PaC patients with diabetes by Western blot. REG Ialpha positive cancer cells in PaC with diabetes (n = 38) was significantly higher than that in subjects without diabetes (n = 42, p < 0.05) by immunohistochemical analysis. Furthermore, we found that overexpression of REG Ialpha protein in PaC cell lines resulted in accelerated cell proliferation and consequently tumor growth, both in vitro and in vivo. The findings suggest that REG Ialpha may act as one of the tumor promoter and contribute to the aggressive nature of PaC, especially in the subpopulation with diabetes. This study would shed new insights for understanding the molecular mechanisms underlying the link between diabetes and PaC. |
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Authors:
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Lin Zhou; Ruifeng Zhang; Lishun Wang; Shaoming Shen; Hiroshi Okamoto; Akira Sugawara; Li Xia; Xiaoling Wang; Naoya Noguchi; Takeo Yoshikawa; Akira Uruno; Weiyan Yao; Yaozong Yuan |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of cancer. Journal international du cancer Volume: 127 ISSN: 1097-0215 ISO Abbreviation: Int. J. Cancer Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-08-30 Completed Date: 2010-09-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0042124 Medline TA: Int J Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 1795-803 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Animals Blotting, Western Cell Proliferation Colony-Forming Units Assay Culture Media, Conditioned / pharmacology Diabetes Mellitus, Type 2 / metabolism*, pathology Female Humans Immunoenzyme Techniques Lithostathine / metabolism* Male Mice Mice, Inbred BALB C Middle Aged Pancreatic Neoplasms / metabolism*, pathology Tumor Cells, Cultured Up-Regulation |
| Chemical | |
Reg. No./Substance:
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0/Culture Media, Conditioned; 0/Lithostathine; 0/REG1A protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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