| Up-and-coming markers: myeloperoxidase, a novel biomarker test for heart failure and acute coronary syndrome application? | |
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MedLine Citation:
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PMID: 18772634 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Myeloperoxidase (MPO) is a mammalian enzyme responsible for generation of hypochlorite. The advantage of myeloperoxidase for use as a biomarker in the setting of heart failure and acute coronary syndrome is the early increase of MPO concentration in response to the acute event. In the setting of heart failure the reported independency of coronary artery disease and general inflammation, as indicated by MPO concentration in comparison to other inflammatory markers or in subgroups of patients with ischemic and non-ischemic cardiomyopathy, has to be highlighted. In terms of ACS, inclusion of MPO into a multiple marker strategy might add to enhance diagnosis and therapy decision making. Therefore, MPO is a biomarker worthwhile of further evaluation in the setting of cardiovascular disease. |
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Authors:
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Christoph Sinning; Renate Schnabel; W Frank Peacock; Stefan Blankenberg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Congestive heart failure (Greenwich, Conn.) Volume: 14 ISSN: 1527-5299 ISO Abbreviation: Congest Heart Fail Publication Date: 2008 Jul-Aug |
Date Detail:
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Created Date: 2008-09-05 Completed Date: 2008-11-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9714174 Medline TA: Congest Heart Fail Country: United States |
Other Details:
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Languages: eng Pagination: 46-8 Citation Subset: IM |
Affiliation:
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Department of Medicine II, Johannes Gutenberg-University Mainz, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Coronary Syndrome
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diagnosis*,
enzymology,
physiopathology Biological Markers Diagnosis, Differential Heart Failure / diagnosis*, enzymology, physiopathology Humans Peroxidase / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; EC 1.11.1.7/Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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