| Up for Mischief? IL-17/Th17 in the tumour microenvironment. | |
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MedLine Citation:
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PMID: 20729908 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of interleukin (IL)-17 and the IL-17-producing T helper (Th)17 cells in cancer has recently become the focus of extensive investigation. An expanding body of literature implicates Th17 cells and their hallmark cytokine in both pro- and anti-tumourigenic processes. In this review we describe their biological activities and outline the reciprocal interactions between Th17 cells and other cells of the immune system. We also discuss the evidence regarding their dual role in the tumour microenvironment. An understanding of the processes that regulate the pro- or anti-tumour activities of Th17 cell and IL-17 will allow the development of more effective means for cancer immunotherapy. |
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Authors:
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E Maniati; R Soper; T Hagemann |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-08-23 |
Journal Detail:
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Title: Oncogene Volume: 29 ISSN: 1476-5594 ISO Abbreviation: Oncogene Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-21 Completed Date: 2010-11-09 Revised Date: 2010-12-03 |
Medline Journal Info:
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Nlm Unique ID: 8711562 Medline TA: Oncogene Country: England |
Other Details:
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Languages: eng Pagination: 5653-62 Citation Subset: IM |
Affiliation:
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Centre for Cancer and Inflammation, Institute of Cancer, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Humans Interleukin-17 / immunology* Neoplasms / immunology* T-Lymphocyte Subsets / immunology* T-Lymphocytes, Helper-Inducer / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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A11251//Cancer Research UK; G0601867(82107)//Medical Research Council; //Cancer Research UK; //Medical Research Council |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-17 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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