| Unveiling the role of network and systems biology in drug discovery. | |
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MedLine Citation:
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PMID: 20117850 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Network and systems biology offer a novel way of approaching drug discovery by developing models that consider the global physiological environment of protein targets, and the effects of modifying them, without losing the key molecular details. Here we review some recent advances in network and systems biology applied to human health, and discuss how they can have a big impact on some of the most interesting areas of drug discovery. In particular, we claim that network biology will play a central part in the development of novel polypharmacology strategies to fight complex multifactorial diseases, where efficacious therapies will need to center on altering entire pathways rather than single proteins. We briefly present new developments in the two areas where we believe network and system biology strategies are more likely to have an immediate contribution: predictive toxicology and drug repurposing. |
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Authors:
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Albert Pujol; Roberto Mosca; Judith Farr?s; Patrick Aloy |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-02-01 |
Journal Detail:
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Title: Trends in pharmacological sciences Volume: 31 ISSN: 1873-3735 ISO Abbreviation: Trends Pharmacol. Sci. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-08 Completed Date: 2010-06-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7906158 Medline TA: Trends Pharmacol Sci Country: England |
Other Details:
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Languages: eng Pagination: 115-23 Citation Subset: IM |
Copyright Information:
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2009 Elsevier Ltd. All rights reserved. |
Affiliation:
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Institute for Research in Biomedicine and Barcelona Supercomputing Center, c/Baldiri i Reixac 10-12, 08028 Barcelona, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Drug Discovery
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methods* Metabolic Networks and Pathways* Systems Biology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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