| Unveiling the mechanisms of cell-cell fusion. | |
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MedLine Citation:
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PMID: 15831748 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cell-cell fusion is fundamental to the development and physiology of multicellular organisms, but little is known of its mechanistic underpinnings. Recent studies have revealed that many proteins involved in cell-cell fusion are also required for seemingly unrelated cellular processes such as phagocytosis, cell migration, axon growth, and synaptogenesis. We review advances in understanding cell-cell fusion by contrasting it with virus-cell and intracellular vesicle fusion. We also consider how proteins involved in general aspects of membrane dynamics have been co-opted to control fusion of diverse cell types by coupling with specialized proteins involved in cell-cell recognition, adhesion, and signaling. |
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Authors:
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Elizabeth H Chen; Eric N Olson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 308 ISSN: 1095-9203 ISO Abbreviation: Science Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-04-15 Completed Date: 2005-04-28 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: United States |
Other Details:
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Languages: eng Pagination: 369-73 Citation Subset: IM |
Affiliation:
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Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. echen@jhmi.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Fusion* Cytoplasmic Vesicles / physiology Cytoskeleton / physiology Disease Humans Membrane Fusion Membrane Proteins / physiology Models, Biological Signal Transduction Therapeutics Viral Fusion Proteins / metabolism Virus Physiological Phenomena |
| Chemical | |
Reg. No./Substance:
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0/Membrane Proteins; 0/Viral Fusion Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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