Document Detail

Unusually prolonged duration of spinal anesthesia following 2% mepivacaine.
MedLine Citation:
PMID:  9690597     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVES: Spinal mepivacaine has been reported as a reliable anesthetic for ambulatory anesthesia. Its pharmacologic properties are midway between those of bupivacaine and lidocaine, and it can be used in intermediate duration ambulatory surgical procedures. METHODS: A patient taking clonidine transdermal patches (TTS) to control high blood pressure received spinal mepivacaine for surgical repair of a ruptured meniscus with arthroscopy. RESULTS: The resulting duration of sensory and motor block were 12 and 8.5 hours, respectively. These are more than four times as long as the reported mean durations with this spinal local anesthetic. We hypothesized that the use of clonidine via TTS for the previous 16 months contributed to this unusual delay of recovery from spinal anesthesia. CONCLUSIONS: Clonidine can increase the duration of spinal anesthetics. Even though this well-known effect has been considered mostly beneficial, it can be an adverse effect when spinal ambulatory anesthesia is given to patients receiving clonidine TTS or clonidine in other forms for long-term treatment of hypertension or other diseases.
V Tagariello; L Bertini
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Regional anesthesia and pain medicine     Volume:  23     ISSN:  1098-7339     ISO Abbreviation:  Reg Anesth Pain Med     Publication Date:    1998 Jul-Aug
Date Detail:
Created Date:  1998-10-06     Completed Date:  1998-10-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9804508     Medline TA:  Reg Anesth Pain Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  424-6     Citation Subset:  IM    
Servizio di Anestesia e Rianimazione, Centro Ortopedico Traumatologico, Rome, Italy.
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MeSH Terms
Administration, Cutaneous
Ambulatory Surgical Procedures
Anesthesia Recovery Period*
Anesthesia, Spinal*
Anesthetics, Local / administration & dosage*
Clonidine / administration & dosage
Mepivacaine / administration & dosage*
Middle Aged
Time Factors
Reg. No./Substance:
0/Anesthetics, Local; 4205-90-7/Clonidine; 96-88-8/Mepivacaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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