Document Detail


Unusually high frequency of autoantibodies to PL-7 associated with milder muscle disease in Japanese patients with polymyositis/dermatomyositis.
MedLine Citation:
PMID:  16732549     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Autoantibodies to aminoacyl transfer RNA synthetases, such as histidyl (Jo-1), threonyl (PL-7), alanyl (PL-12), glycyl (EJ), and isoleucyl (OJ), are closely associated with a subset of patients with polymyositis/dermatomyositis (PM/DM) complicated by interstitial lung disease (ILD). Anti-Jo-1 is by far the most common, found in 15-25% of patients with PM/DM, whereas the other types are found in only approximately 3% of these patients. In this study, the clinical associations of these autoantibodies in Japanese patients with PM/DM were investigated. METHODS: The diagnoses of PM/DM and amyopathic DM (ADM) were based on the Bohan and Peter criteria and Sontheimer's definition, respectively. Sera from 36 Japanese patients with PM/DM (13 with PM, 20 with DM, 3 with ADM) were screened by immunoprecipitation and by enzyme-linked immunosorbent assay (for Jo-1). Clinical and laboratory data were collected. RESULTS: The frequencies of autoantibodies to Jo-1 (22%) and to EJ, OJ, and PL-12 (3-6%) were similar to those found in previous studies, including studies of Japanese subjects. However, anti-PL-7 was found in 17% of patients, in contrast to a frequency of 1-4% in previous studies (P < 0.02-0.0002). The 6 anti-PL-7-positive patients were not related, and no skewing in year or month of disease development, place of residence or work, or occupation was found. All patients had ILD, consistent with the clinical features of antisynthetase-positive patients. The patients with anti-PL-7 had lower serum muscle enzyme levels and milder muscle weakness (P < 0.05) compared with anti-Jo-1-positive patients. CONCLUSION: Anti-PL-7 was found at an unusually high frequency in this group of Japanese patients with myositis. Although anti-PL-7, similar to anti-Jo-1, is associated with PM/DM with ILD, muscle involvement in the patients with anti-PL-7 appeared to be milder than that in the anti-Jo-1 subset.
Authors:
Yoshioki Yamasaki; Hidehiro Yamada; Toshiko Nozaki; Jun Akaogi; Cody Nichols; Robert Lyons; Anthony Chin Loy; Edward K L Chan; Westley H Reeves; Minoru Satoh
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  54     ISSN:  0004-3591     ISO Abbreviation:  Arthritis Rheum.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-19     Completed Date:  2006-07-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2004-9     Citation Subset:  AIM; IM    
Affiliation:
University of Florida, Gainesville, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Alanine-tRNA Ligase / immunology
Asian Continental Ancestry Group
Autoantibodies / blood*
Dermatomyositis / immunology*
Enzyme-Linked Immunosorbent Assay
Female
Glycine-tRNA Ligase / immunology
Histidine-tRNA Ligase / immunology
Humans
Immunoprecipitation
Isoleucine-tRNA Ligase / immunology
Japan
Lung Diseases, Interstitial / complications
Male
Middle Aged
Muscular Diseases / immunology
Polymyositis / immunology
Threonine-tRNA Ligase / immunology*
Grant Support
ID/Acronym/Agency:
M01RR00082/RR/NCRR NIH HHS; R01-AR-40391/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Autoantibodies; EC 6.1.1.14/Glycine-tRNA Ligase; EC 6.1.1.21/Histidine-tRNA Ligase; EC 6.1.1.3/Threonine-tRNA Ligase; EC 6.1.1.5/Isoleucine-tRNA Ligase; EC 6.1.1.7/Alanine-tRNA Ligase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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