| Unusual thyroid constellation in Down syndrome: congenital hypothyroidism, Graves' disease, and hemiagenesis in the same child. | |
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MedLine Citation:
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PMID: 19492583 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report a girl with Down syndrome who was diagnosed with congenital hypothyroidism in the newborn period due to left thyroid hemiagenesis. Unexpectedly, her hypothyroidism resolved at the age of 3 years. After being off thyroid hormone replacement for 7 years and having normal thyroid function, she developed Graves' disease. Although Graves' disease in association with thyroid hemiagenesis has previously been reported, this represents the youngest patient in whom this scenario has been described. Issues pertaining to thyroid hemiagenesis, autoimmune hyperthyroidism, and thyroid disease in children with Down's syndrome are discussed. |
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Authors:
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Todd D Nebesio; Erica A Eugster |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of pediatric endocrinology & metabolism : JPEM Volume: 22 ISSN: 0334-018X ISO Abbreviation: J. Pediatr. Endocrinol. Metab. Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-06-04 Completed Date: 2009-06-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508900 Medline TA: J Pediatr Endocrinol Metab Country: England |
Other Details:
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Languages: eng Pagination: 263-8 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Section of Pediatric Endocrinology/Diabetology, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN 46202, USA. tdnebesi@iupui.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Child Congenital Hypothyroidism / complications*, pathology Down Syndrome / complications*, pathology Female Graves Disease / etiology*, pathology Hashimoto Disease / etiology, pathology Humans Iodine Radioisotopes / diagnostic use Thyroid Dysgenesis / complications*, pathology Thyroid Gland / abnormalities*, ultrasonography Tomography, X-Ray Computed / methods Ultrasonography, Doppler |
| Chemical | |
Reg. No./Substance:
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0/Iodine Radioisotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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