Document Detail

Unusual solute protection against pressure inactivation of yeast alcohol dehydrogenase.
MedLine Citation:
PMID:  16305552     Owner:  NLM     Status:  MEDLINE    
A 3:1 combination of sucrose and glycine provides significantly greater protection against pressure-induced inactivation of yeast alcohol dehydrogenase than either solute alone. Trehalose, alone, gives much greater protection than sucrose alone, but not so in combination with glycine. These are striking new findings that cannot be accounted for by current theories of protein stabilization.
Gene Kidman; Dexter B Northrop
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Protein and peptide letters     Volume:  12     ISSN:  0929-8665     ISO Abbreviation:  Protein Pept. Lett.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-24     Completed Date:  2006-02-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9441434     Medline TA:  Protein Pept Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  801-3     Citation Subset:  IM    
Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705, USA.
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MeSH Terms
Alcohol Dehydrogenase / metabolism*
Amino Acids / metabolism
Carbohydrates / physiology
Enzyme Stability / physiology
Hydrostatic Pressure*
Protein Denaturation / drug effects
Saccharomyces cerevisiae / enzymology*
Time Factors
Reg. No./Substance:
0/Amino Acids; 0/Carbohydrates; EC Dehydrogenase

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