Document Detail

Unusual response to the ajmaline test in a patient with Brugada syndrome.
MedLine Citation:
PMID:  14753634     Owner:  NLM     Status:  MEDLINE    
We present a Brugada syndrome patient who suffered an aborted sudden death. The ajmaline test (1 mg/kg body weight) induced accentuated alternans ST-segment elevation in V1-V2 without ventricular arrhythmias. It could represent silent ischaemia not detected before, failure of myocardial regions to repolarize in alternate beats due to transmural dispersion of conduction and refractoriness in the right ventricular outflow tract or a rate dependent sodium channel block by ajmaline. We need more studies to know whether this electrocardiographic sign is a risk factor for life-threatening ventricular arrhythmias in Brugada syndrome patients.
J Castro Hevia; F Dorticos Balea; M Dorantes Sánchez; R Zayas Molina; M A Quiñones Pérez
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology     Volume:  5     ISSN:  1099-5129     ISO Abbreviation:  Europace     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2004-02-02     Completed Date:  2004-02-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100883649     Medline TA:  Europace     Country:  England    
Other Details:
Languages:  eng     Pagination:  371-3     Citation Subset:  IM    
Arrhythmia Unit, Cardiovascular Surgery and Cardiology Institute, Havana, Cuba.
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MeSH Terms
Ajmaline / diagnostic use*
Anti-Arrhythmia Agents / diagnostic use*
Bundle-Branch Block / physiopathology*
Death, Sudden, Cardiac / etiology*
Electrophysiologic Techniques, Cardiac
Ventricular Fibrillation / complications
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 4360-12-7/Ajmaline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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