| Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6. | |
| | |
MedLine Citation:
|
PMID: 9689056 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
E2F transcription factors play an important role in the regulation of cell cycle progression. We report here the cloning and characterization of an additional member of this family, E2F-6. E2F-6 lacks pocket protein binding and transactivation domains, and it is a potent transcriptional repressor that contains a modular repression domain at its carboxyl terminus. Overproduction of E2F-6 had no specific effect on cell cycle progression in asynchronously growing Saos2 and NIH 3T3 cells, but it inhibited entry into S phase of NIH 3T3 cells stimulated to exit G0. Taken together, these data suggest that E2F-6 can regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. |
| | |
Authors:
|
S Gaubatz; J G Wood; D M Livingston |
Related Documents
:
|
21274376 - A potential oncogenic role of the commonly observed e2f5 overexpression in hepatocellul... 3601956 - Temperature-compensated ultradian rhythms in lower eukaryotes: timers for cell cycles a... 18289546 - Synchronisation of giardia lamblia: identification of cell cycle stage-specific genes a... 9799396 - Cell cycle regulation of a t-type calcium current in early mouse embryos. 19632246 - Phytoestrogen modulation of bone-related cytokines and its impact on cell viability in ... 16842926 - Binding of sialyl lewis x antigen to lectin-like receptors on nk cells induces cytotoxi... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 95 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 1998 Aug |
Date Detail:
|
Created Date: 1998-09-08 Completed Date: 1998-09-08 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 9190-5 Citation Subset: IM |
Affiliation:
|
Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA. |
| Data Bank Information | |
Bank Name/Acc. No.:
|
GENBANK/AF059292 |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
3T3 Cells Amino Acid Sequence Animals Base Sequence Binding Sites Cloning, Molecular Consensus Sequence DNA, Complementary E2F6 Transcription Factor Hela Cells Humans Mice Molecular Sequence Data Recombinant Proteins / genetics, metabolism Repressor Proteins / genetics, metabolism Transcription Factors / genetics, metabolism* Transcription, Genetic |
| Chemical | |
Reg. No./Substance:
|
0/DNA, Complementary; 0/E2F6 Transcription Factor; 0/E2F6 protein, human; 0/E2f6 protein, mouse; 0/Recombinant Proteins; 0/Repressor Proteins; 0/Transcription Factors |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Preparation of functionally active cell-permeable peptides by single-step ligation of two peptide mo...
Next Document: A post-recruitment function for the RNA polymerase III transcription-initiation factor IIIB.