| Unusual primary ocular neoplasm in a child: leiomyosarcoma of the ciliary body. | |
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MedLine Citation:
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PMID: 17990912 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Primary uveal-tract neoplasms are extremely rare in childhood; the most common lesions found are melanocytic. We report here the case of a 7-year-old girl who underwent enucleation of the right eye with clinical suspicion of choroid melanoma as a result of a ciliary body mass that extended to the posterior chamber. Histologically, the neoplasm featured spindle cell morphology, atypia, and mitoses. The tumor expressed smooth muscle alpha actin, pan-actin HHF-35, and desmin, whereas immunohistochemistry for melanocytic markers, such as S-100, Melan-A, and HMB-45, was negative. Based on these features, the diagnosis of leiomyosarcoma of the ciliary body was firmly established. Although several leiomyomas have been reported in the literature, there are only 2 previously reported cases of primary leiomyosarcoma of the uveal tract. Immunohistochemical expression of muscle proteins allowed distinction from the most common melanocytic tumors arising in this location. |
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Authors:
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Mariana M Cajaiba; Martha M Chojniak; Isabela W Cunha |
Publication Detail:
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Type: Case Reports; Journal Article Date: 2007-06-27 |
Journal Detail:
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Title: Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Volume: 11 ISSN: 1093-5266 ISO Abbreviation: Pediatr. Dev. Pathol. Publication Date: 2008 Nov-Dec |
Date Detail:
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Created Date: 2009-01-15 Completed Date: 2009-03-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9809673 Medline TA: Pediatr Dev Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 479-81 Citation Subset: IM |
Affiliation:
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Department of Anatomic Pathology, Hospital do Câncer AC Camargo-São Paulo, Brazil. mmcajaiba@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Proliferation Child Choroid / pathology Ciliary Body / chemistry, pathology*, surgery Diagnosis, Differential Eye Enucleation Female Humans Immunohistochemistry Leiomyosarcoma / chemistry, pathology*, surgery Melanoma / diagnosis Tumor Markers, Biological / analysis Uveal Neoplasms / chemistry, pathology*, surgery |
| Chemical | |
Reg. No./Substance:
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0/Tumor Markers, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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