Document Detail

Unusual primary ocular neoplasm in a child: leiomyosarcoma of the ciliary body.
MedLine Citation:
PMID:  17990912     Owner:  NLM     Status:  MEDLINE    
Primary uveal-tract neoplasms are extremely rare in childhood; the most common lesions found are melanocytic. We report here the case of a 7-year-old girl who underwent enucleation of the right eye with clinical suspicion of choroid melanoma as a result of a ciliary body mass that extended to the posterior chamber. Histologically, the neoplasm featured spindle cell morphology, atypia, and mitoses. The tumor expressed smooth muscle alpha actin, pan-actin HHF-35, and desmin, whereas immunohistochemistry for melanocytic markers, such as S-100, Melan-A, and HMB-45, was negative. Based on these features, the diagnosis of leiomyosarcoma of the ciliary body was firmly established. Although several leiomyomas have been reported in the literature, there are only 2 previously reported cases of primary leiomyosarcoma of the uveal tract. Immunohistochemical expression of muscle proteins allowed distinction from the most common melanocytic tumors arising in this location.
Mariana M Cajaiba; Martha M Chojniak; Isabela W Cunha
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2007-06-27
Journal Detail:
Title:  Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society     Volume:  11     ISSN:  1093-5266     ISO Abbreviation:  Pediatr. Dev. Pathol.     Publication Date:    2008 Nov-Dec
Date Detail:
Created Date:  2009-01-15     Completed Date:  2009-03-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9809673     Medline TA:  Pediatr Dev Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  479-81     Citation Subset:  IM    
Department of Anatomic Pathology, Hospital do Câncer AC Camargo-São Paulo, Brazil.
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MeSH Terms
Cell Proliferation
Choroid / pathology
Ciliary Body / chemistry,  pathology*,  surgery
Diagnosis, Differential
Eye Enucleation
Leiomyosarcoma / chemistry,  pathology*,  surgery
Melanoma / diagnosis
Tumor Markers, Biological / analysis
Uveal Neoplasms / chemistry,  pathology*,  surgery
Reg. No./Substance:
0/Tumor Markers, Biological

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