Document Detail


Unusual presentation of tuberculosis as a splenic mass.
MedLine Citation:
PMID:  16960348     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tuberculosis is an important health problem in developing countries, with varying clinical presentations depending on the organs/systems involved. Tuberculosis is mostly seen in immuno-compromised individuals, such as those with acquired immune deficiency syndrome or malignancies. Here we report a case of a spleen tuberculoma in a 29-year-old male patient with no known immune deficiency. He first presented with abdominal pain, and subsequent ultrasonographic examination revealed a splenic lesion of 10 cm in diameter. A computerized tomography scan of the abdomen confirmed the presence of a solitary, hypodense, septated cystic lesion. Lack of evidence supporting the presence of a splenic infection or a primary/metastatic malignancy prompted explorative surgery where a septated abscess formation was discovered and splenectomy was performed. Histopathological examination revealed granulomatous inflammatory changes with Langerhans-type giant cells, which are consistent with tuberculosis. For a period of two months, antituberculosis therapy with four drugs, isoniazid, rifampicin, pyrazinamide, and ethambutol, was carried out. Pyrazinamide and ethambutol were quitted at the end of two months. Therapy with isoniazid and rifampicin was planned for an additional 10 months. We would like to call attention to yet another atypical presentation of extrapulmonary tuberculosis.
Authors:
Fatih Dede; Elvin Doğan; Mehmet Demir; Didem Sener; Mehmet Kös; Murat Tad; Erdal Eskioğlu
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Tohoku journal of experimental medicine     Volume:  210     ISSN:  0040-8727     ISO Abbreviation:  Tohoku J. Exp. Med.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-08     Completed Date:  2006-10-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417355     Medline TA:  Tohoku J Exp Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  79-82     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Ankara Numune Research and Education Hospital, Turkey. fatded@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Antibiotics, Antitubercular / therapeutic use
Drug Therapy, Combination
Humans
Isoniazid / therapeutic use
Liver / pathology
Lymph Nodes / pathology
Male
Rifampin / therapeutic use
Spleen / drug effects,  pathology*
Splenectomy
Tomography, X-Ray Computed
Tuberculin Test
Tuberculosis, Splenic / diagnosis,  drug therapy,  pathology*
Chemical
Reg. No./Substance:
0/Antibiotics, Antitubercular; 13292-46-1/Rifampin; 54-85-3/Isoniazid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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