Document Detail


Unusual presentation of myeloid sarcoma in a case of acute promyelocytic leukemia with a cryptic PML-RARA rearrangement involving multiple sites including the atrium.
MedLine Citation:
PMID:  20513534     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Myeloid sarcoma is an extramedullary tumor mass composed of immature myeloid cells. Myeloid sarcoma may develop de novo, concurrently with acute myeloid leukemia (AML), or at relapse. Although myeloid sarcoma can occur at any site, myeloid sarcoma involving the heart is extremely rare. Reported here is the case of a 30-year-old man, initially diagnosed with acute promyelocytic leukemia (APL) in bone marrow, who presented later with myeloid sarcoma at multiple anatomical sites (left scapula, thoracic vertebra, right atrium, and supraclavicular mass) in multiple relapses. Conventional cytogenetic studies performed on the atrial sample revealed a karyotype with additional material on the short arm of chromosome 7, at 7p22. Fluorescence in situ hybridization studies confirmed a cryptic PML-RARA fusion on the short arm of chromosome 7, as well as a second fusion on one copy of chromosome 15. With the fourth and latest relapse, molecular cytogenetic studies performed on interphase nuclei of the myeloid sarcoma specimen (a supraclavicular mass) showed evidence of six related abnormal clones with a PML-RARA fusion, suggesting clonal evolution. This represents a rare case of APL with a cryptic PML-RARA rearrangement presenting as myeloid sarcoma at multiple relapses and involving multiple anatomical sites, including cardiac atrium.
Authors:
Carlos A Tirado; Weina Chen; Federico Valdez; Nitin Karandikar; Arnaldo Arbini; Isabel Acevedo; Rolando Garcia; Oscar Davila; Ruth L Smart; Erin Matthews; Angela Kirk; Robert H Collins
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  200     ISSN:  1873-4456     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-01     Completed Date:  2010-06-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  47-53     Citation Subset:  IM    
Copyright Information:
2010 Elsevier Inc. All rights reserved.
Affiliation:
Department of Pathology, The University of Texas Southwestern Medical Center, 75390-9073, USA. carlos1.tirado@utsouthwestern.edu <carlos1.tirado@utsouthwestern.edu>
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MeSH Terms
Descriptor/Qualifier:
Adult
Flow Cytometry
Gene Rearrangement*
Heart Atria / pathology
Heart Neoplasms / genetics*,  immunology,  pathology
Humans
Immunophenotyping
In Situ Hybridization, Fluorescence
Leukemia, Promyelocytic, Acute / genetics*,  immunology,  pathology
Male
Oncogene Proteins, Fusion / genetics*
Sarcoma, Myeloid / genetics*,  immunology,  pathology
Chemical
Reg. No./Substance:
0/Oncogene Proteins, Fusion; 0/promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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