Document Detail

Unusual obliterative disease of the hepatic veins in an infant.
MedLine Citation:
PMID:  143777     Owner:  NLM     Status:  MEDLINE    
Hepatic fibrosis with obliterative lesions of the small hepatic veins occurred in a three month old infant with fatal congenital leukaemia treated with cytostatic drugs. The vascular changes were characterized by an unusual, hitherto unreported angiomatoid, proliferation of the endothelium. The process is compared with the more common subendothelial-fibrous type of the "veno-occlusive disease". An etiological interpretation is difficult, possibly the process is a secondary reaction to the endothelial to a cytostatic-induced lesion with hepatic fibrosis.
A Burkhardt; G Klöppel
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Virchows Archiv. A, Pathological anatomy and histology     Volume:  375     ISSN:  0340-1227     ISO Abbreviation:  Virchows Arch A Pathol Anat Histol     Publication Date:  1977 Sep 
Date Detail:
Created Date:  1977-11-30     Completed Date:  1977-11-30     Revised Date:  2008-02-20    
Medline Journal Info:
Nlm Unique ID:  7505137     Medline TA:  Virchows Arch A Pathol Anat Histol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  225-32     Citation Subset:  IM    
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MeSH Terms
Antineoplastic Agents / adverse effects
Hepatic Veins* / pathology
Leukemia / complications,  congenital
Liver Cirrhosis / complications*
Reg. No./Substance:
0/Antineoplastic Agents

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