Document Detail

Unusual manifestations of monoclonal gammopathies. Autoimmune and idiopathic syndromes.
MedLine Citation:
PMID:  3535495     Owner:  NLM     Status:  MEDLINE    
Manifestations of monoclonal gammopathies are due to four broad mechanisms: destruction of bones, bone marrow, and normal tissues by an expanding tumor; nonspecific effects of large amounts of circulating paraproteins leading to hyperviscosity; autoantibody specificity of paraproteins that give rise to cryoglobulinemia, cold agglutinin disease, and other autoimmune phenomena, as well as incidental binding to bacterial antigens and haptens; and idiopathic syndromes due to as yet unidentified tumor products or other mechanisms. A review with an emphasis on the autoimmune and idiopathic manifestations of monoclonal gammopathies is presented.
D B Duggan; A Schattner
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of medicine     Volume:  81     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1986 Nov 
Date Detail:
Created Date:  1986-12-04     Completed Date:  1986-12-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  864-70     Citation Subset:  AIM; IM    
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MeSH Terms
Antibodies / immunology*
Antibodies, Monoclonal / immunology*
Autoimmune Diseases / complications*
Neoplasms / complications
Paraproteinemias / blood,  etiology,  immunology*
Reg. No./Substance:
0/Antibodies; 0/Antibodies, Monoclonal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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