| Unusual manifestation of acute hepatic porphyria in pregnancy. | |
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MedLine Citation:
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PMID: 17139171 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 22-year-old para I/gravida II developed psychiatric symptoms at 8 weeks of gestation. Subsequently neurological symptoms with seizures developed leading to a status epilepticus with continuing seizures at week 14. Anticonvulsive therapy had little effect in alleviating the seizures and the condition of the patient rapidly deteriorated. A sudden reddening of her urine lead to the diagnosis of acute hepatic porphyria confirmed by laboratory tests. After extensive discussion with the patient's family it was decided to terminate the pregnancy at week 16. Within hours after pregnancy termination the seizures stopped and the patient recovered without any neurological deficits. Acute hepatic porphyria can be triggered by pregnancy and usually presents with gastrointestinal symptoms and personality changes. In its rare neurological manifestation it can lead to untreatable convulsions which leave no option but to terminate the pregnancy. |
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Authors:
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A Weinzierl; C Brezinka; K Engelhardt |
Publication Detail:
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Type: Case Reports; Journal Article Date: 2006-11-28 |
Journal Detail:
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Title: Fetal diagnosis and therapy Volume: 22 ISSN: 1015-3837 ISO Abbreviation: Fetal. Diagn. Ther. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-02-16 Completed Date: 2007-03-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107463 Medline TA: Fetal Diagn Ther Country: Switzerland |
Other Details:
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Languages: eng Pagination: 136-8 Citation Subset: IM |
Affiliation:
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Department of Gynecology and Obstetrics, University of Innsbruck, Innsbruck, Austria. anneliese.weinzierl@uibk.ac.at |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Induced Acute Disease Adult Female Humans Porphyria, Acute Intermittent / complications, diagnosis* Porphyrias, Hepatic / complications, diagnosis Pregnancy Pregnancy Complications / diagnosis* Status Epilepticus / etiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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