| Unusual fusion between ventral and dorsal primordia causes anomalous pancreaticobiliary junction. | |
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MedLine Citation:
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PMID: 18705770 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Anomalous pancreaticobiliary junction (APBJ) is a congenital anomaly in which the pancreatic duct joins the common bile duct proximal to the sphincter of Oddi. Anatomical and immunohistochemical examination of the pancreas with APBJ has rarely been performed. A 72-year-old woman with gallbladder cancer and APBJ died of respiratory failure. Macroscopic features of the pancreas were examined in detail. Immunohistochemistry using anti-pancreatic polypeptide (anti-PP) antibody was done to discriminate ventral and dorsal pancreas. Macroscopically the inferior part of the head of the pancreas was smaller than normal. The posterior surface of the head was obliquely grooved. Part of the pancreatic head protruded into the posterior side of the pancreatic head. A PP-rich region was located in the superioposterior position of the pancreas head. Considering the relationship between the ventral and dorsal pancreas, it was inferred that the ventral primordium could obliquely fuse with the dorsal primordium during embryological development. As a result, APBJ occurs through an abnormal fusion between ventral and dorsal primordia. |
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Authors:
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Hiroyuki Tadokoro; Masaru Takase; Bunsei Nobukawa |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pathology international Volume: 58 ISSN: 1440-1827 ISO Abbreviation: Pathol. Int. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-18 Completed Date: 2008-10-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9431380 Medline TA: Pathol Int Country: Australia |
Other Details:
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Languages: eng Pagination: 498-502 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, Juntendo Tokyo Koto Geriatric Medical Center, Shinsuna, Koto-ku, Tokyo, Japan. heroyou27@yahoo.co.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Biological Markers / metabolism Common Bile Duct / abnormalities*, metabolism Common Bile Duct Diseases / complications, congenital, pathology* Fatal Outcome Female Gallbladder Neoplasms / complications, pathology* Humans Immunoenzyme Techniques Pancreas / abnormalities*, metabolism Pancreatic Ducts / abnormalities*, metabolism Pancreatic Polypeptide / immunology, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 59763-91-6/Pancreatic Polypeptide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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