Document Detail

Unusual five amino acid insert within subtype C HIV-1 envelope contributes to dual-tropism (X4R5).
MedLine Citation:
PMID:  20299967     Owner:  NLM     Status:  MEDLINE    
During the course of HIV infection, some HIV-1 viruses switch from using the CCR5 (R5) coreceptor to using CXCR4 (X4). Here, we describe two subtype C isolates from a Zimbabwean patient that switched from using R5 to using both R5 and X4 with an accompanying addition of five amino acids to the V3 loop region of envelope. The insert appears to be derived from the human genome rather than a duplication within HIV-1.
Elizabeth Johnston White; Bryan McColgan; Seble Kassaye; Lynn Zijenah; David Katzenstein
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  AIDS (London, England)     Volume:  24     ISSN:  1473-5571     ISO Abbreviation:  AIDS     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-13     Completed Date:  2011-01-21     Revised Date:  2014-09-10    
Medline Journal Info:
Nlm Unique ID:  8710219     Medline TA:  AIDS     Country:  England    
Other Details:
Languages:  eng     Pagination:  1063-4     Citation Subset:  IM; X    
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MeSH Terms
Amino Acid Sequence
HIV Infections / genetics*,  virology
HIV-1 / genetics*
Receptors, CCR5 / genetics*,  metabolism
Receptors, CXCR4 / genetics*,  metabolism
Tropism / genetics*
Grant Support
R01 AI060399/AI/NIAID NIH HHS; R01 AI060399-04/AI/NIAID NIH HHS; R01 AI066922/AI/NIAID NIH HHS; U2R TW006878-05/TW/FIC NIH HHS
Reg. No./Substance:
0/Receptors, CCR5; 0/Receptors, CXCR4

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