Document Detail


Unusual five amino acid insert within subtype C HIV-1 envelope contributes to dual-tropism (X4R5).
MedLine Citation:
PMID:  20299967     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During the course of HIV infection, some HIV-1 viruses switch from using the CCR5 (R5) coreceptor to using CXCR4 (X4). Here, we describe two subtype C isolates from a Zimbabwean patient that switched from using R5 to using both R5 and X4 with an accompanying addition of five amino acids to the V3 loop region of envelope. The insert appears to be derived from the human genome rather than a duplication within HIV-1.
Authors:
Elizabeth Johnston White; Bryan McColgan; Seble Kassaye; Lynn Zijenah; David Katzenstein
Related Documents :
17448487 - Functionalized polymer colloids bearing primary amino groups.
421837 - Free amino acids in motor cortex of amyotrophic lateral sclerosis.
749957 - Plasma amino acid quantitation using gas chromatography chemical ionization mass spectr...
15158437 - Determination of amino acid pairs sensitive to variants in human copper-transporting at...
23445007 - Characteristic oxygen k-edge circular dichroism spectra of amino acid films by improved...
3403397 - Glycerolipid biosynthesis in porcine adipose tissue in vitro. ii. synthesis by various ...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  AIDS (London, England)     Volume:  24     ISSN:  1473-5571     ISO Abbreviation:  AIDS     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-13     Completed Date:  2011-01-21     Revised Date:  2012-10-09    
Medline Journal Info:
Nlm Unique ID:  8710219     Medline TA:  AIDS     Country:  England    
Other Details:
Languages:  eng     Pagination:  1063-4     Citation Subset:  IM; X    
Affiliation:
Stanford University, Stanford, California 94305, USA. betsyj@stanford.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Amino Acid Sequence
HIV Infections / genetics*,  virology
HIV-1 / genetics*
Humans
Receptors, CCR5 / genetics*,  metabolism
Receptors, CXCR4 / genetics*,  metabolism
Tropism / genetics*
Grant Support
ID/Acronym/Agency:
R01 AI060399-04/AI/NIAID NIH HHS; R01 AI066922/AI/NIAID NIH HHS; U2R TW006878-05/TW/FIC NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, CCR5; 0/Receptors, CXCR4
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Impairment in kidney tubular function in patients receiving tenofovir is associated with higher teno...
Next Document:  Cerebrospinal fluid in HIV-1 systemic viral controllers: absence of HIV-1 RNA and intrathecal inflam...