| Unusual five amino acid insert within subtype C HIV-1 envelope contributes to dual-tropism (X4R5). | |
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MedLine Citation:
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PMID: 20299967 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During the course of HIV infection, some HIV-1 viruses switch from using the CCR5 (R5) coreceptor to using CXCR4 (X4). Here, we describe two subtype C isolates from a Zimbabwean patient that switched from using R5 to using both R5 and X4 with an accompanying addition of five amino acids to the V3 loop region of envelope. The insert appears to be derived from the human genome rather than a duplication within HIV-1. |
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Authors:
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Elizabeth Johnston White; Bryan McColgan; Seble Kassaye; Lynn Zijenah; David Katzenstein |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: AIDS (London, England) Volume: 24 ISSN: 1473-5571 ISO Abbreviation: AIDS Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-13 Completed Date: 2011-01-21 Revised Date: 2012-10-09 |
Medline Journal Info:
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Nlm Unique ID: 8710219 Medline TA: AIDS Country: England |
Other Details:
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Languages: eng Pagination: 1063-4 Citation Subset: IM; X |
Affiliation:
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Stanford University, Stanford, California 94305, USA. betsyj@stanford.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amino Acid Sequence HIV Infections / genetics*, virology HIV-1 / genetics* Humans Receptors, CCR5 / genetics*, metabolism Receptors, CXCR4 / genetics*, metabolism Tropism / genetics* |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI060399-04/AI/NIAID NIH HHS; R01 AI066922/AI/NIAID NIH HHS; U2R TW006878-05/TW/FIC NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, CCR5; 0/Receptors, CXCR4 |
| Comments/Corrections | |
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