| Unusual consequences of status epilepticus in Dravet syndrome. | |
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MedLine Citation:
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PMID: 20172746 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although status epilepticus (SE) affects the course of Dravet syndrome (DS), it rarely alters dramatically psychomotor outcome. We report an unusual pattern in 3 patients who following refractory SE lasting respectively 2, 7 and 12h experienced persistent and severe cognitive and motor deterioration. We compared these patients to published data and to personal experience in Necker hospital, to find links between severe outcome and clinical features such as treatment or duration of refractory SE. The key point was that anoxoischemic-like lesions appeared on MRI although cardiovascular function had remained stable. Therefore, neither hemodynamic failure, nor abnormalities of cardiac rhythm could explain the lesions and neurological worsening. For theoretical reasons the responsibility of therapy common for the 3 patients, e.g., barbiturates was suspected. |
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Authors:
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M Chipaux; N Villeneuve; P Sabouraud; I Desguerre; N Boddaert; C Depienne; C Chiron; O Dulac; R Nabbout |
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Publication Detail:
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Type: Journal Article Date: 2010-02-20 |
Journal Detail:
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Title: Seizure : the journal of the British Epilepsy Association Volume: 19 ISSN: 1532-2688 ISO Abbreviation: Seizure Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-08 Completed Date: 2010-06-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9306979 Medline TA: Seizure Country: England |
Other Details:
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Languages: eng Pagination: 190-4 Citation Subset: IM |
Copyright Information:
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(c) 2010 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Service de neurop?diatrie, Centre de r?f?rence ?pilepsies rares, AP-HP, H?pital Necker Enfants Malades, Paris, France. mathilde.chipaux@nck.aphp.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anticonvulsants
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adverse effects Barbiturates / adverse effects Brain / blood supply, pathology* Child, Preschool Developmental Disabilities / etiology Epilepsy / drug therapy, genetics, pathology* Humans Infant Magnetic Resonance Imaging Mutation Nerve Tissue Proteins / genetics Sodium Channels / genetics Status Epilepticus / drug therapy, genetics, pathology* Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Barbiturates; 0/Nerve Tissue Proteins; 0/Sodium Channels; 0/sodium channel, voltage-gated, type I, alpha protein |
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