| Unusual combination of paraneoplastic manifestations in a patient with metastatic gastrointestinal stromal tumor (GIST). | |
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MedLine Citation:
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PMID: 19086169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. Activating mutations in tyrosine kinase receptors KIT or platelet-derived growth factor receptor alpha (PDGFRA) are the main mechanisms causing the disease. Patients generally present with non-specific symptoms, while a number of tumors are discovered incidentally and may be metastatic at the time of diagnosis. Aggressive GISTs have a defined pattern of metastasis to the liver or throughout the abdomen, or both. Though GISTs rarely present systemic or isolated paraneoplastic reactions, a few cases have been reported in the literature. We present the case of a 54-year-old patient with metastatic GIST at diagnosis and the emergence of paraneoplastic manifestations during follow-up. |
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Authors:
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Spyridon Tsikrikas; Spilios Manolakopoulos; Melanie Deutsch; Georgios Alexakis; Konstantinos Sialevris; Dimitrios Giannopoulos; Dimitrios Vassilopoulos; Athanasios J Archimandritis |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Scandinavian journal of gastroenterology Volume: 43 ISSN: 0036-5521 ISO Abbreviation: Scand. J. Gastroenterol. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-12-15 Completed Date: 2009-01-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0060105 Medline TA: Scand J Gastroenterol Country: Norway |
Other Details:
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Languages: eng Pagination: 1012-5 Citation Subset: IM |
Affiliation:
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2nd Academic Department of Internal Medicine, University of Athens, Hippokration General Hospital, Athens, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biopsy Cecal Diseases / diagnosis, etiology* Colonoscopy Follow-Up Studies Gastrointestinal Stromal Tumors / complications, pathology* Humans Hypoglycemia / diagnosis, etiology* Liver Neoplasms / complications, diagnosis, secondary* Magnetic Resonance Imaging Male Middle Aged Paraneoplastic Syndromes / diagnosis, etiology* Tomography, X-Ray Computed |
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