Document Detail


Unusual combination of paraneoplastic manifestations in a patient with metastatic gastrointestinal stromal tumor (GIST).
MedLine Citation:
PMID:  19086169     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. Activating mutations in tyrosine kinase receptors KIT or platelet-derived growth factor receptor alpha (PDGFRA) are the main mechanisms causing the disease. Patients generally present with non-specific symptoms, while a number of tumors are discovered incidentally and may be metastatic at the time of diagnosis. Aggressive GISTs have a defined pattern of metastasis to the liver or throughout the abdomen, or both. Though GISTs rarely present systemic or isolated paraneoplastic reactions, a few cases have been reported in the literature. We present the case of a 54-year-old patient with metastatic GIST at diagnosis and the emergence of paraneoplastic manifestations during follow-up.
Authors:
Spyridon Tsikrikas; Spilios Manolakopoulos; Melanie Deutsch; Georgios Alexakis; Konstantinos Sialevris; Dimitrios Giannopoulos; Dimitrios Vassilopoulos; Athanasios J Archimandritis
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  43     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-12-15     Completed Date:  2009-01-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  1012-5     Citation Subset:  IM    
Affiliation:
2nd Academic Department of Internal Medicine, University of Athens, Hippokration General Hospital, Athens, Greece.
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MeSH Terms
Descriptor/Qualifier:
Biopsy
Cecal Diseases / diagnosis,  etiology*
Colonoscopy
Follow-Up Studies
Gastrointestinal Stromal Tumors / complications,  pathology*
Humans
Hypoglycemia / diagnosis,  etiology*
Liver Neoplasms / complications,  diagnosis,  secondary*
Magnetic Resonance Imaging
Male
Middle Aged
Paraneoplastic Syndromes / diagnosis,  etiology*
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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