Document Detail

Unusual clustering of Alu repeats within the 5'-flanking region of the human lysozyme gene.
MedLine Citation:
PMID:  8173077     Owner:  NLM     Status:  MEDLINE    
We report the nucleotide sequence of the 2.2-kb 5'-flanking region of the human lysozyme gene. Four Alu repeats are located within this upstream region. Classification and dating of these four Alu elements, as well as of the four Alu elements present within the human lysozyme structural gene, were performed. Transposition of the eight Alu repeats found in the human lysozyme locus has apparently occurred at four different times during the primate genome evolution. Considering that Alu repeats are interspersed throughout human DNA with an average spacing of 4 kb, the presence of eight such repeats within the 8-kb lysozyme gene region and, in particular, of four of them in the 2.2-kb region upstream of the structural gene, appears quite unusual.
M L Riccio; G M Rossolini
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  DNA sequence : the journal of DNA sequencing and mapping     Volume:  4     ISSN:  1042-5179     ISO Abbreviation:  DNA Seq.     Publication Date:  1993  
Date Detail:
Created Date:  1994-06-03     Completed Date:  1994-06-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9107800     Medline TA:  DNA Seq     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  129-34     Citation Subset:  IM    
Dipartimento di Biologia Molecolare, Università degli Studi di Siena, Italy.
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MeSH Terms
Base Sequence
DNA / genetics
Genome, Human
Hominidae / genetics*
Molecular Sequence Data
Muramidase / genetics*
Primates / genetics
Promoter Regions, Genetic*
Repetitive Sequences, Nucleic Acid*
Restriction Mapping
Sequence Homology, Nucleic Acid
Reg. No./Substance:
9007-49-2/DNA; EC

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