Document Detail


Unusual clinicopathological and immunological presentation of chronic bullous dermatosis of childhood (linear IgA dermatosis).
MedLine Citation:
PMID:  22121282     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Linear IgA bullous dermatosis is a rare sulfone-responsive subepidermal blistering disorder of unknown etiology in which smooth linear deposits of IgA are found in the basement membrane zone. Chronic bullous dermatosis of childhood is equivalent to linear IgA disease of adulthood and is characterized by an abrupt onset of large, widespread and tense bullae on a normal or erythematous base. In this case, we describe an unusual presentation of chronic bullous dermatosis in a 14-month-old Saudi girl. Histopathological examination revealed subepidermal cell poor blisters with linear deposition of IgA, IgG, IgM, and C3 along the dermoepidermal junction. The unusual clinical, histopathological and immunofluorescence findings in this patient are discussed, with an account on the differential diagnosis in such cases along with a detailed review of the relevant literature.
Authors:
Al-Saif Fahad; Al-Rikabi Ammar
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of dermatology     Volume:  56     ISSN:  1998-3611     ISO Abbreviation:  Indian J Dermatol     Publication Date:    2011 Sep-Oct
Date Detail:
Created Date:  2011-11-28     Completed Date:  2012-08-23     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0370750     Medline TA:  Indian J Dermatol     Country:  India    
Other Details:
Languages:  eng     Pagination:  573-5     Citation Subset:  -    
Affiliation:
Department of Dermatology, King Khalid University Hospital and King Saud University, Riyadh, Kingdom of Saudi Arabia.
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