| Unusual clinical presentation in a patient with myelodysplastic syndrome, with subsequent hematological remission and suppression of the malignant clone following treatment with cyclosporine A, erythropoietin and granulocyte colony-stimulating factor. | |
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MedLine Citation:
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PMID: 10374866 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 35-year-old female presented with isolated thrombocytopenia of autoimmune origin. One and a half years later, hypoplastic myelodysplastic (MDS) was diagnosed. Following treatment with cyclosporin A, erythropoietin and granulocyte colony-stimulating factor, the patient has achieved a sustained hematological remission which is still ongoing after 3 years. Furthermore, to the best of our knowledge, this is the third case described in the literature where treatment with cytokines alone or in combination with immunosuppressive agents has resulted in a long standing cytogenetic response in MDS. |
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Authors:
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J Samuelsson; G Lärfars |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Leukemia research Volume: 23 ISSN: 0145-2126 ISO Abbreviation: Leuk. Res. Publication Date: 1999 May |
Date Detail:
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Created Date: 1999-07-07 Completed Date: 1999-07-07 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7706787 Medline TA: Leuk Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 513-7 Citation Subset: IM |
Affiliation:
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Department of Hematology, The Karolinska Institute at Huddinge University Hospital, Sweden. jan.samuelsson@hematol.hs.sll.se |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Autoimmune Diseases / drug therapy, pathology Cyclosporine / therapeutic use* Disease Progression Drug Therapy, Combination Erythropoietin / therapeutic use* Female Granulocyte Colony-Stimulating Factor / therapeutic use* Humans Myelodysplastic Syndromes / drug therapy*, pathology Platelet Count / drug effects Remission Induction / methods Thrombocytopenia / drug therapy, pathology |
| Chemical | |
Reg. No./Substance:
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11096-26-7/Erythropoietin; 143011-72-7/Granulocyte Colony-Stimulating Factor; 59865-13-3/Cyclosporine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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