Document Detail


Unusual clinical manifestation of linear IgA dermatosis: a report of two cases.
MedLine Citation:
PMID:  15280828     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Linear IgA dermatosis is a rare autoimmune bullous skin disease with subepidermal blister formation and linear IgA deposits along the basement membrane zone. We describe two female patients showing erythematous annular plaques with scaling at the margin, strictly localized to the palms in one patient, and also found on the soles and buttocks in the second patient. Histology showed numerous neutrophils in the dermis with an admixture of eosinophils, some subepidermal clefting, and occasional papillary microabscesses. Direct immunofluorescence and immunoelectron microscopy revealed in vivo IgA deposition along the basement membrane zone. One patient cleared after treatment with dapsone. The second patient did not respond to dapsone alone and various immunosuppressive treatment regimens. Considerable improvement was achieved with intravenous immunoglobulin therapy combined with corticosteroid and dapsone.
Authors:
Karla Cauza; Gabriele Hinterhuber; Barbara Sterniczky; Karin Brugger; Friederike Pieczkowski; Franz Karlhofer; Klaus Wolff; Dagmar Foedinger
Related Documents :
6827588 - Systemic lupus erythematosus and iga deficiency.
20609138 - Transient hypogammaglobulinemia and unclassified hypogammaglobulinemia: 'similarities a...
3495948 - Comparison of the postoperative changes in the humoral and cellular immune activity in ...
943578 - Serum immunoglobulins in genitourinary malignancies.
7847948 - The role of thoracoscopy in the diagnosis of interstitial lung disease.
7519418 - Hyperbilirubinemia without common bile duct abnormalities and hyperamylasemia without p...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  51     ISSN:  1097-6787     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-28     Completed Date:  2005-02-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S112-7     Citation Subset:  IM    
Affiliation:
Division of General Dermatology, Department of Dermatology, University of Vienna, School of Medicine, Austria. karla.cauza@gmx.at
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Dapsone / therapeutic use
Female
Hand
Hemidesmosomes / ultrastructure
Humans
Immunoglobulin A / analysis*
Microscopy, Immunoelectron
Remission Induction
Skin Diseases / diagnosis*,  drug therapy,  pathology
Chemical
Reg. No./Substance:
0/Immunoglobulin A; 80-08-0/Dapsone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Interstitial granulomatous dermatitis secondary to soy.
Next Document:  Self-resolution of Epstein-Barr virus-associated B-cell lymphoma in a patient with dermatomyositis f...