Document Detail

Unusual clinical manifestation of linear IgA dermatosis: a report of two cases.
MedLine Citation:
PMID:  15280828     Owner:  NLM     Status:  MEDLINE    
Linear IgA dermatosis is a rare autoimmune bullous skin disease with subepidermal blister formation and linear IgA deposits along the basement membrane zone. We describe two female patients showing erythematous annular plaques with scaling at the margin, strictly localized to the palms in one patient, and also found on the soles and buttocks in the second patient. Histology showed numerous neutrophils in the dermis with an admixture of eosinophils, some subepidermal clefting, and occasional papillary microabscesses. Direct immunofluorescence and immunoelectron microscopy revealed in vivo IgA deposition along the basement membrane zone. One patient cleared after treatment with dapsone. The second patient did not respond to dapsone alone and various immunosuppressive treatment regimens. Considerable improvement was achieved with intravenous immunoglobulin therapy combined with corticosteroid and dapsone.
Karla Cauza; Gabriele Hinterhuber; Barbara Sterniczky; Karin Brugger; Friederike Pieczkowski; Franz Karlhofer; Klaus Wolff; Dagmar Foedinger
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  51     ISSN:  1097-6787     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-28     Completed Date:  2005-02-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S112-7     Citation Subset:  IM    
Division of General Dermatology, Department of Dermatology, University of Vienna, School of Medicine, Austria.
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MeSH Terms
Aged, 80 and over
Dapsone / therapeutic use
Hemidesmosomes / ultrastructure
Immunoglobulin A / analysis*
Microscopy, Immunoelectron
Remission Induction
Skin Diseases / diagnosis*,  drug therapy,  pathology
Reg. No./Substance:
0/Immunoglobulin A; 80-08-0/Dapsone

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