| Unusual ciliary abnormalities in three 9/11 response workers. | |
| | |
MedLine Citation:
|
PMID: 21370679 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
After the 9/11 terrorist attacks on the World Trade Center in New York in 2001, thousands of response workers were exposed to complex mixtures of toxins, pollutants, and carcinogens. Many developed illnesses involving the respiratory tract. We report unusual ultrastructural ciliary abnormalities in 3 response workers that corresponded to their respiratory and ciliary functional abnormalities. Each patient had respiratory cilia biopsies that were evaluated for motility and ultrastructural changes. Impaired ciliary motility was seen in 2 of the 3 patients. Each of the patients showed monomorphic ultrastructural abnormalities. Two of the patients showed identical triangular disarray of axonemal microtubules with peripheral doublets 1,4, and 7 forming the corners of the triangle and doublet 9 always more medially displaced than doublets 2, 3, 5, 6, and 8. Two workers had cilia in which axonemes were replaced by homogeneously dense cores. One of these also had cilia with triangular axonemes as previously described. The other had cilia with a geometric triangular to pentagonal shape. The ciliary abnormalities described here may represent a new class of primary ciliary dyskinesia in which abnormalities may have a genetic basis and a phenotypic expression that is prompted at the cellular level by local environmental conditions. |
| | |
Authors:
|
James T McMahon; Rizwan Aslam; Stephen E Schell |
Related Documents
:
|
15025219 - Telomere length in leukocytes and cultured gingival fibroblasts from patients with aggr... 3050019 - Enzyme activity in crevicular fluid for detection and prediction of clinical attachment... 9793799 - Neutrophil functions and il-8 in psoriatic arthritis and in cutaneous psoriasis. 3712419 - Chronic granulomatous disease in a 23-year-old female. 16401649 - Formation of immature neutrophil leucocytes in schizophrenic patients treated with vari... 4044049 - Neutrophil and monocyte adherence in diabetes mellitus, alcoholic cirrhosis, uraemia an... 982109 - Fantasy and self-esteem of renal dialysis patients and their spouses. 20422909 - Cardiac autonomic dysfunction in patients with systemic lupus, rheumatoid arthritis and... 21705259 - Levodopa ameliorated anorectal constipation in de novo parkinson's disease: the ql-gat ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Annals of otology, rhinology, and laryngology Volume: 120 ISSN: 0003-4894 ISO Abbreviation: Ann. Otol. Rhinol. Laryngol. Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-03-04 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0407300 Medline TA: Ann Otol Rhinol Laryngol Country: United States |
Other Details:
|
Languages: eng Pagination: 40-8 Citation Subset: AIM; IM |
Affiliation:
|
Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, Ohio, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Carbon dioxide laser-assisted endoscopic cricopharyngeal myotomy with primary mucosal closure.
Next Document: Laryngeal regeneration using tissue engineering techniques in a canine model.