| Unusual case of severe cholestasis of pregnancy with early onset, improved by ursodeoxycholic acid administration. | |
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MedLine Citation:
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PMID: 9481568 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An exceptional case of early onset and prolonged postpartum course of intrahepatic cholestasis of pregnancy is described. Contrary to other drugs tested, ursodeoxycholic acid administered after the 29th week of gestation improved pruritus and decreased bile acid levels both in serum and amniotic fluid. Labour was induced at 36 weeks, and a female weighing 2.050 g and with an Apgar score of nine was born. Ursodeoxycholic acid, by decreasing the passage of bile acids to the foetus, may have improved the outcome of the pregnancy. |
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Authors:
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D Brites; C M Rodrigues; M da C Cardoso; L M Graça |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 76 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 1998 Feb |
Date Detail:
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Created Date: 1998-03-26 Completed Date: 1998-03-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: IRELAND |
Other Details:
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Languages: eng Pagination: 165-8 Citation Subset: IM |
Affiliation:
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Centro de Patogénese Molecular, Faculdade de Farmácia da Universidade de Lisboa, Portugal. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amniotic Fluid / metabolism Bile Acids and Salts / blood, metabolism Cholestasis, Intrahepatic / complications, drug therapy*, metabolism Female Humans Labor, Induced Pregnancy Pregnancy Complications / drug therapy* Pregnancy Outcome Pruritus / etiology Ursodeoxycholic Acid / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts; 128-13-2/Ursodeoxycholic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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