Document Detail

Unusual case of metastatic neuroendocrine tumor.
MedLine Citation:
PMID:  17360306     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To report a rare case of metastatic growth hormone (GH)-secreting pituitary carcinoma causing acromegaly. METHODS: We present a case report and review the available literature on this topic. RESULTS: A 68-year-old woman presented with persistent acromegaly after treatment for a GH-secreting pituitary adenoma. Evaluation of long-standing cervical adenopathy revealed findings consistent with a metastatic neuroendocrine tumor. Further work-up revealed additional thyroid, parathyroid, and cervical masses. After operative treatment including total thyroidectomy, subtotal parathyroidectomy, partial thymectomy, and right modified radical neck dissection, the patient's symptoms diminished, and her GH levels approached the normal range. Surgical pathology findings were consistent with a GH-secreting pituitary carcinoma metastatic to the cervical lymph nodes, multinodular thyroid hyperplasia with a focus of papillary microcarcinoma, and parathyroid hyperplasia. CONCLUSION: Overall, pituitary carcinomas are extremely rare. To date, about 100 cases have been reported in the world's literature, and of these, only 19 cases originated from GH-secreting cells. Our examination of the symptoms, signs, diagnosis, and treatment of our patient, in comparison with the previously reported cases, should enhance awareness of this unusual disease process.
Michele A Manahan; Alan P B Dackiw; Douglas W Ball; Martha A Zeiger
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists     Volume:  13     ISSN:  1934-2403     ISO Abbreviation:  Endocr Pract     Publication Date:    2007 Jan-Feb
Date Detail:
Created Date:  2007-03-15     Completed Date:  2007-04-12     Revised Date:  2007-10-30    
Medline Journal Info:
Nlm Unique ID:  9607439     Medline TA:  Endocr Pract     Country:  United States    
Other Details:
Languages:  eng     Pagination:  72-6     Citation Subset:  IM    
Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
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MeSH Terms
Acromegaly / etiology
Adenoma / complications,  pathology*,  surgery
Growth Hormone-Secreting Pituitary Adenoma / complications,  pathology*,  surgery
Lymphatic Metastasis
Parathyroid Neoplasms / complications,  secondary*,  surgery
Thymus Neoplasms / complications,  secondary*,  surgery
Thyroid Neoplasms / complications,  secondary*,  surgery

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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