Document Detail

Unusual atrophic change after repeated arterial therapy for hepatocellular carcinoma: report of a case.
MedLine Citation:
PMID:  14714235     Owner:  NLM     Status:  MEDLINE    
We report the case of a 45-year-old man with advanced hepatocellular carcinoma (HCC) who was able to undergo radical surgery after repeated transarterial therapy. Transarterial chemoembolization was repeated three times, and thereafter, transarterial infusion chemotherapy using Lipiodol was performed on the right hepatic artery. Because notable atrophy of the right lobe and compensated hypertrophy of the left lobe were detected after this therapy, an extended right lobectomy could be performed. Histologically, the HCC showed complete necrosis. The remarkable atrophic change of the right lobe was thought to be due to an obstruction of the right portal veins by the spread of inflammation around the bile duct necrosis, in addition to the narrowing of the hepatic artery. A thorough understanding of this phenomenon and the development of methods to clinically apply it in the treatment of cancer patients may thus lead to an increase in the percentage of resectable cases of advanced HCC.
Takamichi Komori; Yo Sasaki; Terumasa Yamada; Hiroaki Ohigashi; Osamu Ishikawa; Etsuo Inoue; Shingo Ishiguro; Toshihito Seki; Shingi Imaoka
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Surgery today     Volume:  34     ISSN:  0941-1291     ISO Abbreviation:  Surg. Today     Publication Date:  2004  
Date Detail:
Created Date:  2004-01-09     Completed Date:  2004-05-19     Revised Date:  2006-08-03    
Medline Journal Info:
Nlm Unique ID:  9204360     Medline TA:  Surg Today     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  76-9     Citation Subset:  IM    
Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3 Nakamichi, Higasinari-ku, Osaka 537-8511, Japan.
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MeSH Terms
Carcinoma, Hepatocellular / drug therapy*,  pathology
Chemoembolization, Therapeutic*
Infusions, Intra-Arterial
Iodized Oil / therapeutic use*
Liver Neoplasms / drug therapy*,  pathology
Middle Aged
Reg. No./Substance:
8001-40-9/Iodized Oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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