| Unusual D-lactic acid acidosis from propylene glycol metabolism in overdose. | |
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MedLine Citation:
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PMID: 15214621 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To report a case of D-lactic acid acidosis owing to massive oral ingestion of propylene glycol. CASE REPORT: A 72-year old man with known congestive failure was admitted to the ICU with encephalopathy. Twelve hours prior to admission he had erroneously ingested a large amount of propylene glycol (PG). The laboratory revealed high anion gap (anion gap = 27 meq/l) acidosis (arterial pH = 7.16) and an increased osmolal gap. Toxicological analysis revealed a low serum propylene glycol level. Biochemical analysis indicated that very high amounts of D-lactic acid (up to 110 mmol/l), but not of the usual type of L-lactic acid, were responsible for the metabolic acidosis. Hemodialysis was initiated and associated with a decline of both the acidosis and D-lactic acid levels. The patient regained conciousness. CONCLUSION: Ingestion of massive doses of propylene glycol, previously not reported as a cause of D-lactic acidosis, should be added to the differential diagnosis of this rare condition. |
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Authors:
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Philippe G Jorens; Hendrik E Demey; Paul J C Schepens; Vera Coucke; Gert A Verpooten; M M Couttenye; Viviane Van Hoof |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of toxicology. Clinical toxicology Volume: 42 ISSN: 0731-3810 ISO Abbreviation: J. Toxicol. Clin. Toxicol. Publication Date: 2004 |
Date Detail:
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Created Date: 2004-06-24 Completed Date: 2004-07-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8213460 Medline TA: J Toxicol Clin Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 163-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Intensive Care Medicine, University Hospital of Antwerp, Edegem, Belgium. Philippe.Jorens@uza.be |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acidosis, Lactic
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chemically induced*,
pathology Aged Brain Diseases, Metabolic / etiology Fatal Outcome Humans Male Overdose Propylene Glycol / metabolism, poisoning* Solvents / metabolism, poisoning* Stereoisomerism |
| Chemical | |
Reg. No./Substance:
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0/Solvents; 57-55-6/Propylene Glycol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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