Document Detail


An Unusual Case of Elderly-Onset Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) With Multiple Cerebrovascular Risk Factors.
MedLine Citation:
PMID:  20851625     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Here we report a female patient with elderly-onset cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). At age 71, she developed gait disturbance, followed by memory disturbance 1 year later. She had been treated for hypertension and diabetes mellitus for 19 years. There apparently was low penetrance of disease. Magnetic resonance imaging (MRI) findings showed typical features of CADASIL, and the R607C mutation was detected in exon 11 in NOTCH3. This case strongly indicates that CADASIL should be considered when typical findings are observed on MRI even in cases of elderly onset with multiple cerebrovascular risk factors.
Authors:
Mitsunori Watanabe; Yoshiki Adachi; Mandy Jackson; Yukiko Yamamoto-Watanabe; Yasuhito Wakasaya; Ikumi Shirahama; Ayumi Takamura; Etsuro Matsubara; Takeshi Kawarabayashi; Mikio Shoji
Related Documents :
21590995 - Magnetic resonance imaging evaluation of renal structure and function related to diseas...
9632185 - Regional cerebral blood volume after severe head injury in patients with regional cereb...
18839005 - Bold-mri cerebrovascular reactivity findings in cocaine-induced cerebral vasculitis.
263625 - Posterior fossa intra-axial tumors: a comparison of computed tomography with other imag...
23652215 - Clinical impact of early brain atrophy in clinically isolated syndromes.
15333795 - Lung image database consortium: developing a resource for the medical imaging research ...
Publication Detail:
Type:  Journal Article     Date:  2010-09-19
Journal Detail:
Title:  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association     Volume:  21     ISSN:  1532-8511     ISO Abbreviation:  J Stroke Cerebrovasc Dis     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111633     Medline TA:  J Stroke Cerebrovasc Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  143-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 National Stroke Association. Published by Elsevier Inc. All rights reserved.
Affiliation:
Department of Neurology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Metabolic syndrome is a risk factor for acute cerebral infarction in a younger elderly kurashiki pop...
Next Document:  Brachial artery approach for endovascular treatment of posterior circulation intracranial vascular d...