Document Detail


Unsuspected leiomyosarcoma: treatment with a gonadotropin-releasing hormone analogue.
MedLine Citation:
PMID:  2106109     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We present a case of a 46-year-old woman evaluated for abnormal uterine bleeding and an enlarged uterus, with normal endometrial sampling. Three months of leuprolide acetate injections resulted in a nonenlarging uterus and resolution of iron deficiency anemia and menorrhagia. Intraoperative examination suggested leiomyosarcoma, which was confirmed by postoperative permanent histologic sections. Residual uterine sarcomatous disease was confirmed on reexploration. Similar cases will continue to raise arguments against conservative hormonal intervention in the perimenopausal woman with an enlarged uterus. As the gynecologist gains familiarity with the use of gonadotropin-releasing hormone analogue therapy in the treatment of myomatous uteri, the criteria for hysterectomy will become less rigid and the potential for delay in the diagnosis and treatment of sarcomatous disease will become more common. Physicians must be cognizant of this potential complication of conservative therapy of leiomyomata uteri.
Authors:
W R Meyer; A R Mayer; M P Diamond; M L Carcangiu; P E Schwartz; A H DeCherney
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  75     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-03-20     Completed Date:  1990-03-20     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  529-32     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / therapeutic use*
Female
Gonadotropin-Releasing Hormone / analogs & derivatives*,  therapeutic use
Humans
Leiomyosarcoma / drug therapy*,  pathology,  surgery
Leuprolide
Middle Aged
Uterine Neoplasms / drug therapy*,  pathology,  surgery
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 33515-09-2/Gonadotropin-Releasing Hormone; 53714-56-0/Leuprolide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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