| Unsuspected leiomyosarcoma: treatment with a gonadotropin-releasing hormone analogue. | |
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MedLine Citation:
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PMID: 2106109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We present a case of a 46-year-old woman evaluated for abnormal uterine bleeding and an enlarged uterus, with normal endometrial sampling. Three months of leuprolide acetate injections resulted in a nonenlarging uterus and resolution of iron deficiency anemia and menorrhagia. Intraoperative examination suggested leiomyosarcoma, which was confirmed by postoperative permanent histologic sections. Residual uterine sarcomatous disease was confirmed on reexploration. Similar cases will continue to raise arguments against conservative hormonal intervention in the perimenopausal woman with an enlarged uterus. As the gynecologist gains familiarity with the use of gonadotropin-releasing hormone analogue therapy in the treatment of myomatous uteri, the criteria for hysterectomy will become less rigid and the potential for delay in the diagnosis and treatment of sarcomatous disease will become more common. Physicians must be cognizant of this potential complication of conservative therapy of leiomyomata uteri. |
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Authors:
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W R Meyer; A R Mayer; M P Diamond; M L Carcangiu; P E Schwartz; A H DeCherney |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 75 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 1990 Mar |
Date Detail:
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Created Date: 1990-03-20 Completed Date: 1990-03-20 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 529-32 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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therapeutic use* Female Gonadotropin-Releasing Hormone / analogs & derivatives*, therapeutic use Humans Leiomyosarcoma / drug therapy*, pathology, surgery Leuprolide Middle Aged Uterine Neoplasms / drug therapy*, pathology, surgery |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 33515-09-2/Gonadotropin-Releasing Hormone; 53714-56-0/Leuprolide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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