Document Detail

Unsuspected colchicine overdose in a female patient presenting as an acute abdomen.
MedLine Citation:
PMID:  17591144     Owner:  NLM     Status:  MEDLINE    
We report a case of multi-system organ failure as a result of unsuspected colchicine overdose in a patient with known gout and bulimia nervosa. The patient had initially presented with mild gastrointestinal symptoms with rapid progression to fulminant hepatic failure and multiple organ dysfunction before the causative agent was identified. The patient survived with aggressive intensive care support and ongoing medical treatment. Physicians should be aware of the risk assessment based on the ingested dose, that the clinical presentation of colchicine in toxic doses may be nonspecific with high potential for severe morbidity or death and that survival may occur despite multiple organ failure requinng aggressive support.
R E Blackham; M Little; S Baker; B M Augustson; G C MacQuillan
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Anaesthesia and intensive care     Volume:  35     ISSN:  0310-057X     ISO Abbreviation:  Anaesth Intensive Care     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-26     Completed Date:  2007-08-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0342017     Medline TA:  Anaesth Intensive Care     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  437-9     Citation Subset:  IM    
Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.
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MeSH Terms
Abdomen, Acute / chemically induced*,  therapy
Colchicine / poisoning*
Diagnosis, Differential
Gout / drug therapy
Gout Suppressants / poisoning*
Liver Failure, Acute / chemically induced
Multiple Organ Failure / chemically induced*,  therapy
Treatment Outcome
Reg. No./Substance:
0/Gout Suppressants; 64-86-8/Colchicine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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